Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillar Manduca sexta

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Shelley A Adamo, Laura E McMillan

Abstract

Immune-nociceptor connections are found in animals across phyla. Local inflammation and/or damage results in increased nociceptive sensitivity of the affected area. However, in mammals, immune responses far from peripheral nociceptors, such as immune responses in the gut, produce a general increase in peripheral nociceptive sensitivity. This phenomenon has not, to our knowledge, been found in other animal groups. We found that consuming heat-killed pathogens reduced the tactile force needed to induce a defensive strike in the caterpillar Manduca sexta. This increase in the nociceptive sensitivity of the body wall is probably part of the reconfiguration of behaviour and physiology that occurs during an immune response (e.g. sickness behaviour). This increase may help enhance anti-predator behaviour as molecular resources are shifted towards the immune system. This article is part of the Theo Murphy meeting issue 'Evolution of mechanisms and behaviour important for pain'.

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Citations

Sep 24, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Edgar T Walters, Amanda C de C Williams
Jan 15, 2020·The Journal of Experimental Biology·Daniel P CaronBarry A Trimmer
Jun 13, 2020·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Shelley A Adamo
Sep 19, 2020·Current Opinion in Insect Science·Alexander Haverkamp, Hans M Smid

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