Listeria monocytogenes intragastric and intraperitoneal approximate 50% lethal doses for mice are comparable, but death occurs earlier by intragastric feeding.

Infection and Immunity
L PineB D Plikaytis

Abstract

The intraperitoneal (i.p.) and intragastric (i.g.) mouse approximate 50% lethal dose values (ALD50S) were determined for 15 food and clinical isolates of Listeria monocytogenes. Although all strains gave i.g. ALD50S comparable to or less than their i.p. ALD50S, the i.g. feeding of most strains produced more deaths within the first 3 days of the 6-day test than did i.p. injection. ALD50S ranged from 50 to 4.4 x 10(5) cells with approximately 1-log 95% confidence intervals. Of five strains tested by suspension in milk or by growth in milk, none gave i.g. ALD50S that were lower than those of washed cells. Results with 10- to 21-g mice supported the use of 15-g mice for i.g. testing; 21-g mice were more resistant to i.g. infection. These results indicate that i.g. feeding permits an evaluation of the role of the carrier (such as milk) in the determination of listerial virulence, permits strain characterization by i.p. and i.g. ALD50S, and emphasizes a potentially more rapid infection when the bacterium is introduced i.g.

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Citations

Mar 24, 2007·Foodborne Pathogens and Disease·Hamdollah Moshtaghi, Ahmad Ali Mohamadpour
Nov 11, 2008·Foodborne Pathogens and Disease·Nancy FaithCharles Czuprynski
Mar 3, 2017·MSphere·Arturo Casadevall
Jan 5, 2002·Food Additives and Contaminants·A D Hitchins, R C Whiting
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Feb 25, 2006·Journal of Food Protection·Yuhuan ChenVirginia N Scott
Jun 1, 2002·Applied and Environmental Microbiology·Charles J CzuprynskiHoward Steinberg
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·C J Czuprynski, N G Faith
Apr 25, 2006·Journal of Food Protection·Kazue TakeuchiMary Alice Smith
Feb 13, 2016·Molecular Microbiology·Patricia A SpearsPaul E Orndorff
Feb 16, 2018·BioMed Research International·Konstantin A SobyaninSvetlana A Ermolaeva
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Jul 1, 1993·Applied and Environmental Microbiology·E R MyersS E Martin
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