PMID: 9423863Jan 10, 1998Paper

Listeria monocytogenes virulence factors that stimulate endothelial cells

Infection and Immunity
D A Drevets

Abstract

Listeria monocytogenes infection of endothelial cells upregulates surface expression of adhesion molecules and stimulates neutrophil adhesion to infected cell monolayers. The experiments presented here tested the roles of specific bacterial virulence factors as triggers for this inflammatory phenotype and function. Human umbilical vein endothelial cell (HUVEC) monolayers were infected with wild-type L. monocytogenes or L. monocytogenes mutants; then surface expression of E-selectin and neutrophil adhesion were measured. The results showed that delta hly and prfA mutants were the most crippled, requiring 100-fold more mutant bacteria than wild-type bacteria for analogous stimulation. By comparison, L. monocytogenes mutants with deletions of actA, inlA, inlB, inlAB, plcA, and plcB resembled their parent strains, and a delta plcA delta plcB mutant displayed decreased intracellular growth rate but only a minor decrease in stimulation of E-selectin or neutrophil adhesion. Other experiments showed that cytochalasin D-treated HUVEC monolayers bound bacteria, but internalization and increased surface E-selectin and intercellular adhesion molecule-1 expression were profoundly inhibited. However, cytochalasin D had no effect on the HUVEC...Continue Reading

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Citations

Dec 24, 2002·Infection and Immunity·Hélène Réglier-PoupetPatrick Berche
Dec 18, 2013·Microbiology·Renata Stavracakis PeixotoAna Luíza Mattos-Guaraldi
Apr 16, 2004·Clinical Microbiology Reviews·Douglas A DrevetsRonald A Greenfield
Feb 28, 2002·The Journal of Infectious Diseases·Edward J Wing, Stephen H Gregory
Nov 15, 2002·Journal of Food Protection·Sophia Kathariou
Aug 20, 2009·Critical Reviews in Food Science and Nutrition·Robert L BuchananElizabeth Julien
Nov 10, 2009·Applied and Environmental Microbiology·Krishnendu MukherjeeTrinad Chakraborty
Apr 7, 2012·Journal of Oncology·Anu WallechaJohn Rothman
Jul 4, 2001·Clinical Microbiology Reviews·J A Vázquez-BolandJ Kreft
Nov 22, 2002·FEMS Immunology and Medical Microbiology·In-Chol Kang, Howard K Kuramitsu
Dec 24, 2018·International Journal of Environmental Research and Public Health·Giovanni SotgiuAndrea Piana
Aug 31, 2018·European Journal of Immunology·Christoph Konradt, Christopher A Hunter
Aug 1, 2006·Thrombosis Research·Sanjeev K Sahni
Oct 29, 2021·FEBS Open Bio·Laura Monturiol-GrossAlberto Alape-Girón
Jul 28, 2011·Vaccine·Abolfazl JahangiriSaeed Khalili

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