Listing Low-Weight or Ill Infants for Heart Transplantation: Is It Prudent?

The Annals of Thoracic Surgery
Raheel RizwanDavid L Morales

Abstract

Infants awaiting heart transplantation (HTx) have the highest waitlist mortality than other HTx patients. This study analyzed the impact of weight and other factors on waitlist and post-HTx outcomes in infants. All infants on the HTx waitlist in the United Network for Organ Sharing database from October 1987 to June 2016 were divided into the following weight groups: less than 2.5 kg, 2.5 to 3.9 kg, and more than 4 kg. Survival from listing regardless of transplantation was compared by using Kaplan-Meier analysis. Of 4,711 infants listed for HTx, 250 (5.3%) weighed less than 2.5 kg, 1,993 (42%) weighed 2.5 to 3.9 kg, and 2,468 (52%) weighed more than 4 kg. Median time on the waitlist was similar between the groups weighing less than 2.5 kg and 2.5 to 3.9 kg (28 days versus 31 days, p = 0.423), whereas the group weighing more than 4 kg waited longer (42 days; p = 0.027 and p < 0.001). Infants weighing less than 2.5 kg (1 year, 43%) had the worst survival from listing regardless of transplantation compared with other groups (versus weighing 2.5 to 3.9 kg: 1 year, 54%, p = 0.001; versus weighing >4 kg: 1 year, 66%, p < 0.001). For infants weighing less than 2.5 kg on ventilator support, the 1 year-survival was 35%, on extracorpore...Continue Reading

Citations

May 7, 2021·World Journal for Pediatric & Congenital Heart Surgery·Othman A AljohaniJohn J Nigro
Jun 8, 2021·The Annals of Thoracic Surgery·David C ClevelandDavid K C Cooper

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