Lisuride hydrogen maleate: an ergoline with beta-adrenergic antagonist activity

European Journal of Pharmacology
T E CoteJ W Kebabian

Abstract

Lisuride hydrogen maleate is identified as a potent beta-adrenergic antagonist using a hormone-sensitive adenylate cyclase system and [3H]dihydroalprenolol binding in cell free homogenates of rabbit cerebellum. Lisuride and two other ergolines, lergotrile and bromocriptine, and the phenothiazine, fluphenazine, all interact with spiroperidol binding sites (dopamine receptors) in the anterior pituitary; however, among these compounds lisuride is unique in its ability to antagonize the beta-adrenoceptor.

References

Jan 1, 1991·Journal of Neural Transmission. General Section·M R CarratùF Federico
Jan 1, 1981·Journal of Neural Transmission·G P Reynolds, P Riederer
Feb 1, 1986·Pharmacology, Biochemistry, and Behavior·F J White
Jan 1, 1984·Clinical Neurology and Neurosurgery·K Burton, D B Calne

Related Concepts

Solocyte
Pituitary Hormones, Anterior
Phenothiazine
Aphasia, Broca
Ergolines
Chinchilla Rabbits
Lisuride, (8alpha)-(+-)-Isomer
Adrenergic Receptor
Novodrin
Hydrogen maleate

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