Lithium absorption, distribution and clearance and body temperature in rats given lithium plus haloperidol

Pharmacology
D SmithM Schou

Abstract

Renal lithium clearance, tissue lithium levels, serum lithium concentration, and body temperature were determined in rats given lithium alone or combined with haloperidol (0.5-1 mg/kg). A slight increase in serum lithium concentration occurred in one of the three groups given lithium plus haloperidol. Haloperidol failed to affect renal lithium clearance, tissue lithium levels and body temperature. The data do not support the hypothesis that haloperidol exerts an action on lithium pharmacokinetics.

References

Dec 1, 1980·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·A M Ghadirian, H E Lehmann

Related Concepts

Exertion
Assay OF Haloperidol
Brain
Lithium Measurement
Myocardium
Kidney
Haloperidol
Haldol
Drug Kinetics
Metazoa

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