PMID: 6401711Jan 1, 1983Paper

Lithium and carbamazepine interaction: possible neurotoxicity

The Journal of Clinical Psychiatry
R P Chaudhry, B G Waters

Abstract

A case is described of a 22-year-old woman with bipolar affective disorder who developed severe neurotoxic symptoms when treated with a combined regimen of lithium carbonate and carbamazepine in therapeutic doses. An open A-B-C-B trial of the two medications separately and concurrently implicated a synergistic interaction between the two.

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