Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania

Journal of Psychiatric Research
Luciano K JornadaJoão Quevedo

Abstract

In this study, we assessed the oxidative stress parameters in rats submitted to an animal model of mania induced by ouabain (OUA), which included the use of lithium (Li) and valproate (VPA). Li and VPA treatment reversed and prevented the OUA-induced damage in these structures, however, this effect varies depending on the brain region and treatment regimen. Moreover, the activity of the antioxidant enzymes, namely, superoxide dismutase (SOD) and catalase (CAT) was found to be increased and decreased, respectively, in the brain of OUA-administered rats. Li and VPA modulated SOD and CAT activities in OUA-subjected rats in both experimental models. Our results support the notion that Li and VPA exert antioxidant-like properties in the brain of rats submitted to animal model of mania induced by ouabain.

Citations

Sep 26, 2012·Journal of Neurology·Ashok SriramMichael S Okun
Jan 27, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adriana Mary Nunes Costa OkamuraDanielle Macêdo
Nov 8, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ajaykumar N SharmaJoao Quevedo
Feb 16, 2013·Neurochemistry International·Amanda V SteckertJoão Quevedo
Sep 25, 2012·Journal of Psychiatric Research·Fernando V GhedimAlexandra I Zugno
Oct 10, 2012·Bipolar Disorders·Klaus MunkholmLars Vedel Kessing
Sep 1, 2015·Neuroscience·R W Logan, C A McClung
Jul 21, 2015·Redox Report : Communications in Free Radical Research·Oliwia Gawlik-KotelnickaDominik Strzelecki
Mar 19, 2013·European Journal of Pharmacology·Marjelo A Mines
Mar 31, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·César Augusto BrüningCristina Wayne Nogueira
Oct 2, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seung-Yup LeeChi-Un Pae
Oct 23, 2016·Free Radical Biology & Medicine·Luiz K S KanazawaRoberto Andreatini
Dec 7, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Samira S ValvassoriJoão Quevedo
Oct 12, 2017·The International Journal of Neuropsychopharmacology·Samira S ValvassoriJoão Quevedo
Nov 20, 2019·International Clinical Psychopharmacology·Hossein Sanjari MoghaddamShahin Akhondzadeh
Aug 3, 2012·Expert Review of Neurotherapeutics·Helena Kyunghee Kim, Ana Cristina Andreazza
Mar 7, 2017·Frontiers in Cellular Neuroscience·Yeni KimMaria C Marchetto
Jul 22, 2018·Molecular Neurobiology·Gustavo C Dal-PontSamira S Valvassori
Jan 5, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Vânia Machado RecartRoselia Spanevello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Rafael E RiegelJoão Quevedo
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Zhifei WangDe-Maw Chuang
© 2021 Meta ULC. All rights reserved