Lithium antagonism of ethanol-induced intoxication: relationship to intracellular lithium levels

Psychiatry Research
J HirschowitzK Dains

Abstract

Seventeen detoxified chronic alcoholics participated in a double-blind trial comparing placebo and lithium (Li+) effects on acute ethanol (1 g/kg) intoxication. In a repeated measures, split-half crossover design, subjects were maintained for 7 days on Li+ or placebo before the ethanol challenge. Plasma Li+ levels on day 7 averaged 1.3 +/- 0.3 mM. Li+ was not more effective than placebo in attenuating ethanol effects across the subjective dimensions of intoxication, desire to drink, and control of drinking and across the cognitive dimensions measured by Trail Making A, Speed of Closure, and the Minnesota Clerical Test. Li+ was not significantly more effective than placebo in preventing the ethanol-induced rise in plasma prolactin. Subjects were divided according to high and low red blood cell (RBC) Li+ intracellular/extracellular Li+ ratios. In a comparison of the Li+ to placebo arms of the trial, the high ratio subjects (n = 9) showed a significant 44% decrease in ethanol-induced intoxication, while the low ratio subjects (n = 8) showed a 15% increase. Furthermore, the high ratio subjects performed better than the low ratio subjects, independent of the ethanol effect, on all tests of cognitive performance. These preliminary da...Continue Reading

References

Apr 1, 1977·Archives of General Psychiatry·L L JuddK I Takahashi
Feb 1, 1989·Biological Psychiatry·R HitzemannD Garver
Mar 1, 1987·Archives of General Psychiatry·J FawcettR D Gibbons
Jul 1, 1987·The American Journal of Psychiatry·M A SchuckitC Risch
Jul 1, 1974·The American Journal of the Medical Sciences·N S KlineO Canal
Aug 23, 1974·European Journal of Clinical Pharmacology·M LinnoilaM Maki
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Dec 1, 1984·The American Journal of Psychiatry·L L Judd, L Y Huey
Jan 1, 1980·The Journal of Membrane Biology·B E Ehrlich, J M Diamond
Apr 3, 1980·The New England Journal of Medicine·M CanessaD C Tosteson
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH

❮ Previous
Next ❯

Citations

Apr 24, 2010·CNS Spectrums·Icro MaremmaniHagop Akiskal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Related Papers

The American Journal of Psychiatry
L L Judd, L Y Huey
Biological Psychiatry
R HitzemannD Garver
Acta Psychiatrica Scandinavica
M T Abou-Saleh, A Coppen
© 2022 Meta ULC. All rights reserved