PMID: 2119851Jun 25, 1990Paper

Lithium augments fos protoonocogene expression in PC12 pheochromocytoma cells: implications for therapeutic action of lithium

Brain Research
V D KalasapudiH M Lachman

Abstract

It has been proposed that lithium's antimanic action is due to an effect on phosphoinositide metabolism. Second messengers generated by this pathway regulate calcium mobilization and the activity of the serine and threonine kinase, protein kinase C (PKC). Included among the targets of PKC is activation of fos protooncogene expression, a well-established component of the AP-1 transcription factor. Because of these interactions, we investigated the effect of lithium on fos gene expression in PC12 pheochromocytoma cells. We find that lithium increases the level of fos mRNA that occurs in response to receptor and postreceptor activation of PKC. Treatment with lithium also leads to an augmentation of muscarinic cholinergic-mediated fos gene expression in cells that are down-regulated as a result of excessive cholinergic stimulation. The ability of lithium to enhance the response of a down-regulated cholinergic system suggests a model for its therapeutic efficacy in affective disorders.

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Citations

Feb 9, 1994·Biochemical Pharmacology·R S Jope, M B Williams
Jun 1, 1992·Brain Research. Molecular Brain Research·H M LachmanF A Henn
Jan 1, 1992·Brain Research. Molecular Brain Research·E D WeinerH M Lachman
Aug 1, 1998·Brain Research. Molecular Brain Research·P X YuanH K Manji
Jun 25, 1999·Brain Research. Molecular Brain Research·B ChenL T Young
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Feb 4, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Alessandro Serretti, Paola Artioli
Mar 4, 2000·Archives of Biochemistry and Biophysics·J E Rodriguez-GilJ J Guinovart
Jul 10, 2010·Journal of Neurogenetics·Erika PedrosaHerbert M Lachman
Apr 26, 1991·Brain Research·C HeurteauxM Thellier
Jul 5, 1991·Brain Research·E D WeinerH M Lachman
Sep 1, 1995·Medical Hypotheses·H M Lachman, D F Papolos
Jan 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiujun SunMartin Alda
Dec 3, 1999·Journal of Neurochemistry·P YuanH K Manji
Jan 31, 1991·Biochemical and Biophysical Research Communications·B A BramiG Hauser
Nov 28, 2006·Archives of Biochemistry and Biophysics·Josep M Fernández-NovellJoan J Guinovart

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