PMID: 6405638Jun 1, 1983Paper

Lithium carbonate and L-tryptophan in the treatment of bipolar and schizoaffective disorders

The American Journal of Psychiatry
T D Brewerton, V I Reus

Abstract

The authors review theoretical and clinical data supporting the hypothesis that L-tryptophan may potentiate the effects of lithium carbonate and report on a double-blind clinical comparison of lithium plus L-tryptophan and lithium plus placebo in 9 bipolar and 7 schizoaffective patients. Overall the combination of lithium and L-tryptophan resulted in significantly greater improvement. However, the results may have been confounded by the greater, although nonsignificant, doses of neuroleptics administered to the group receiving L-tryptophan. The authors discuss the interactions of lithium and L-trypotophan with the serotonin system.

Citations

May 1, 1985·Journal of Affective Disorders·S P Tyrer
Feb 1, 1997·Journal of Affective Disorders·E AlvarezR Noguera
Aug 1, 1991·Acta Psychiatrica Scandinavica·J KrauseO Benkert
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