PMID: 8586486Jul 1, 1995Paper

Lithium chloride enhances survival of NZB/W lupus mice: influence of melatonin and timing of treatment

International Journal of Immunopharmacology
S P LenzD A Hart

Abstract

Daily administration of 4 mg 6LiCl to groups (15 mice/group) of female NZB/W mice starting at 8 weeks of age led to long-term survival (44 weeks of age) of 73% of the mice when injections were performed between 08:00 and 10:00 h and 67% of mice when injections were performed between 17:00 and 19:00 h. Untreated controls were dead by 34 weeks of age and the differences between untreated and treated groups was significant (P < or = 10(-4)). In contrast daily administration of melatonin (100 micrograms/mouse) did not significantly enhance survival when injections were performed between 17:00 and 19:00 h but did enhance survival when given between 08:00 and 10:00 h (P < or = 10(-3)). Differences between the two melatonin groups was also significant (P < or = 0.05). Mice treated with Li plus melatonin exhibited survival curves identical to mice treated with Li alone. Therefore, the Li effect was dominant and survival was not altered by melatonin. Cessation of treatment in long-term survivors at 44 weeks of age led to the rapid death of 80% of the mice previously treated between 17:00 and 19:00 h (Li, Li + melatonin). In contrast, only 40% of the long-term survivors in the other groups had died by 66 weeks of age (22 weeks post-treat...Continue Reading

References

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Citations

Aug 22, 2001·Biological Psychiatry·M H Rapaport, H K Manji
Jun 5, 2002·Mechanisms of Ageing and Development·Russel J ReiterSusanne Burkhardt
Apr 3, 2003·Experimental Gerontology·Vladimir N AnisimovAnatoli I Yashin
Jul 11, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·V N AnisimovA I Yashin
Dec 31, 2009·Biological Reviews of the Cambridge Philosophical Society·Dun-Xian TanRussel J Reiter
Feb 3, 1999·Annals of the New York Academy of Sciences·R J ReiterD Acuña-Castroviejo
Dec 17, 2008·Digestive Diseases and Sciences·Ali DaneshmandAhamd Reza Dehpour
Oct 20, 2009·Trends in Immunology·Eléonore BeurelRichard S Jope
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
Apr 8, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M H Abdel-Wahab, A R Abd-Allah
Nov 19, 2015·Journal of the American Society of Nephrology : JASN·Mohammad AlsadyTheun de Groot
Oct 31, 2003·Toxicologic Pathology·Vladimir N Anisimov
Apr 24, 2013·International Journal of Molecular Sciences·Antonio Carrillo-VicoJuan M Guerrero
Apr 29, 2016·American Journal of Physiology. Renal Physiology·Rujun GongLance Dworkin
Aug 12, 2021·Physiological Genomics·Theun de GrootRon Korstanje
Sep 18, 2021·Aging Cell·Tobias NespitalLinda Partridge

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