PMID: 8994220Dec 20, 1996Paper

Lithium decreases turnover of arachidonate in several brain phospholipids

Neuroscience Letters
M C ChangS I Rapoport

Abstract

In vivo rates of incorporation and turnover of palmitate and arachidonate in brain phospholipids were measured in awake rats treated chronically with lithium, following intravenous infusion of radiolabeled palmitate and arachidonate, respectively. Chronic lithium, at a brain level considered to be therapeutic in humans, decreased turnover of arachidonate within brain phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by up to 80% (P < 0.001). In contrast, lithium had a minimal effect on turnover of palmitate, causing only a 26% reduction in turnover in phosphatidylcholine (P < 0.01). These results suggest that a major therapeutic effect of lithium is to reduce turnover specifically of arachidonate, possibly by inhibiting phospholipase A2 involved in signal transduction. The effect may be secondary to the known action of lithium on the phosphoinositide cycle, by inhibiting the activity of inositol monophosphatase.

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May 1, 1987·Biological Psychiatry·N E JosephJ S Leigh
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Citations

Feb 19, 2005·Psychopharmacology·Sandra GhelardoniFrancesca Bosetti
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·P D Skosnik, J K Yao
Nov 19, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Bradley S FolleySohee Park
Nov 21, 2002·Pharmacology & Therapeutics·Nadia Gurvich, Peter S Klein
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Apr 7, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
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Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mireille BasselinStanley I Rapoport
Sep 6, 2000·Journal of the European Academy of Dermatology and Venereology : JEADV·R WolfM L Lombardi
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Nov 29, 2007·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ho-Joo LeeRichard P Bazinet
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Mar 10, 2004·Bipolar Disorders·M Elizabeth SubletteGwenn S Smith

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