PMID: 6981795Jun 1, 1982Paper

Lithium distribution across the membrane of motoneurons in the isolated frog spinal cord

Pflügers Archiv : European journal of physiology
P GrafeG ten Bruggencate

Abstract

Lithium sensitive microelectrodes were used to investigate the transmembrane distribution of lithium ions (Li+) in motoneurons of the isolated frog spinal cord. After addition of 5 mmol.1(-1) LiCl to the bathing solution the extracellular diffusion of Li+ was measured. At a depth of 500 micrometers, about 60 min elapsed before the extracellular Li+ concentration approached that of the bathing solution. Intracellular measurements revealed that Li+ started to enter the cells soon after reaching the motoneuron pool and after up to 120 min superfusion, an intra - to extracellular concentration ratio of about 0.7 was obtained. The resting membrane potential and height of antidromically evoked action potentials were not altered by 5 mmol.1(-1) Li+.

References

Aug 3, 1979·Brain Research·R A Gorkin, E Richelson
Aug 1, 1976·Pharmacology, Biochemistry, and Behavior·M A Spirtes
May 1, 1980·The Journal of Physiology·R A Davidoff, J C Hackman
Jan 1, 1980·The Journal of Membrane Biology·B E Ehrlich, J M Diamond
Apr 3, 1957·The Journal of Physiology·J M RITCHIE, R W STRAUB

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Citations

Jul 1, 1983·Journal of Neuroscience Methods·J L MunozJ A Coles
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·W WalzL Hertz
Oct 1, 1988·The Journal of Clinical Investigation·H H RasmussenR E ten Eick

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