PMID: 41412Aug 1, 1979

Lithium effects: relation to lithium dose and to plasma peak levels

Acta Psychiatrica Scandinavica
E T MellerupO J Rafaelsen


In a 24-hour study, plasma peak lithium was determined in manic-melancholic patients who routinely had their entire lithium dose at night. A correlation analysis was undertaken of the relation of plasma peak level and the dose of lithium to a number of lithium induced changes: Increase in urine volume, weight gain, decrease in plasm phosphate, increase in plasma magnesium, decrease in plasma urea, increase in plasma alkaline phosphatase, increase in urinary pH. Only the changes in plasma phosphate and in urine pH were significantly correlated to the peak value of plasma lithium. The increase in urine volume was significantly correlated to the dose of lithium.


Nov 1, 1983·Acta Psychiatrica Scandinavica·H Bendz
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Jan 1, 1981·Psychopharmacology·E T MellerupO J Rafaelsen
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Feb 1, 1991·Journal of Clinical Pharmacy and Therapeutics·H R Markar, G Ascough
Apr 1, 1981·Acta Psychiatrica Scandinavica·P PlengeT Nørgaard
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·P Plenge, E T Mellerup


Apr 1, 1976·Kidney International·J M RoscoeB J Stinebaugh
Jan 1, 1975·Neuropsychobiology·C ChristiansenI Transbol
Jan 1, 1976·Acta Psychiatrica Scandinavica·P BechO J Rafaelsen
Feb 1, 1976·Acta Psychiatrica Scandinavica·P B VendsborgO J Rafaelsen
Jan 1, 1973·Acta Psychiatrica Scandinavica·P B VendsborgO J Rafaelsen
Jan 1, 1973·International Pharmacopsychiatry·E T MellerupO J Rafaelsen
Jan 1, 1971·International Pharmacopsychiatry·P PlengeO J Rafaelsen

Related Concepts

Lithium Measurement
Alkaline Phosphatase Measurement
Phosphate Measurement
Alkaline Phosphatase
Manic Disorder
Plasma Urea
Phosphate ion
Hydrogen-Ion Concentration

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