PMID: 2508166Jan 1, 1989Paper

Lithium increases 5-HT-mediated prolactin release

Psychopharmacology
S L McCanceP J Cowen

Abstract

The effects of short-term (3-4 days) lithium treatment on the prolactin responses to intravenous clomipramine (0.1 mg/kg), metoclopramide (5 micrograms/kg) and haloperidol (2.5-5 micrograms/kg) were assessed in male volunteers. Prolactin responses to clomipramine were significantly enhanced by lithium while those following administration of haloperidol and metoclopramide were not significantly altered. Lithium did not change the cortisol response to clomipramine. The results suggest that lithium may selectively enhance 5-HT mediated prolactin release. These data are consistent with the hypothesis that synergistic effects of lithium and clomipramine on brain 5-HT function may be involved in their therapeutic effect in resistant depression.

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Citations

Jun 1, 1993·Biological Psychiatry·A C PowerP J Cowen
May 14, 1992·European Journal of Pharmacology·M E Otero Losada, M C Rubio
Dec 13, 2001·Psychiatry Research·A El KhouryR Stain-Malmgren
Apr 11, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·M BaştürkI Yabanoğlu
Mar 1, 1991·Baillière's Clinical Endocrinology and Metabolism·S Checkley
Jan 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·T P Wakefield
Jun 4, 2010·Human Psychopharmacology·Subramoniam MadhusoodananCarolina Jimenez
Dec 1, 2003·Acta Neuropsychiatrica·B Corbella, E Vieta
Sep 1, 2000·Acta Neuropsychiatrica·A H YoungC H Ashton
Nov 4, 2000·The British Journal of Psychiatry : the Journal of Mental Science·J H HughesA H Young
Sep 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P J CowenD L Julier

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