Abstract
Lithium, a simple monovalent cation, is the mainstay in the treatment of manic-depressive illness, but despite extensive research, its mechanism of action remains to be elucidated. Because lithium requires chronic administration for therapeutic efficacy and because its beneficial effects last well beyond its discontinuation, it has been postulated that lithium may exert major effects at the genomic level. We have previously shown that lithium, at therapeutically relevant concentrations, increases gene expression through the activator protein-1 (AP-1) transcription factor pathway in vitro. In the present study, we have sought to determine if lithium also increases the expression of endogenous genes known to be regulated by AP-1 and have therefore investigated the effects of lithium on tyrosine hydroxylase (TH) levels. Male Wistar rats were treated with LiCl for 9 days (subacute) or 4 weeks (chronic), and TH levels were measured in frontal cortex, hippocampus, and striatum using immunoblotting. Chronic (but not subacute) lithium treatment resulted in significant increases in TH levels in rat frontal cortex, hippocampus, and striatum. Lithium (1 mM) also increased TH levels in human SH-SY5Y neuroblastoma cells in vitro, indicating...Continue Reading
Citations
Feb 4, 1999·Journal of Neurochemistry·G ChenH K Manji
Sep 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mara L CordeiroJoy A Umbach
Nov 3, 2005·Journal of Toxicology and Environmental Health. Part a·Wonsuk Yang, Evelyn Tiffany-Castiglioni
Jan 23, 2010·The European Journal of Neuroscience·Rulun ZhouHusseini K Manji
May 23, 2000·Journal of Neurochemistry·M L CordeiroC B Gundersen
Feb 18, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·B E Leonard
Apr 23, 2002·Pharmacogenomics·Alessandro Serretti
Jan 5, 2002·The Journal of Biological Chemistry·Zoltán H NémethGyörgy Haskó
Jan 18, 2013·Cellular and Molecular Neurobiology·Raymond FarahZaher Arraf
Nov 19, 2015·Frontiers in Neuroscience·Carol A Lazzara, Yong-Hwan Kim
Mar 8, 2003·The Journal of Biological Chemistry·Ifeanyi J Arinze, Yumiko Kawai
Dec 21, 2002·The European Journal of Neuroscience·Alison E WillingPaul R Sanberg
Feb 26, 1999·Journal of Neurochemistry·G ChenH K Manji
Mar 20, 2001·Bipolar Disorders·J PerezR Zanardi
Feb 4, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Alessandro Serretti, Paola Artioli
Jun 22, 2001·The Journal of Biological Chemistry·P X YuanG Chen
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sungho MaengHusseini K Manji
Aug 16, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rulun ZhouHusseini K Manji
Sep 22, 2005·Journal of Neuroscience Research·Corinne M SpencerThomas A Houpt
Apr 28, 2018·Journal of Neurotrauma·Shaun W Carlson, C Edward Dixon
Mar 16, 2001·Bipolar Disorders·G ChenH K Manji
Oct 8, 1999·Psychosomatic Medicine·G ChenH K Manji
Dec 3, 1999·Journal of Neurochemistry·P YuanH K Manji
Apr 12, 2008·Bipolar Disorders·Anna K WisteMark D Underwood
Jan 13, 2006·Journal of Neuroscience Research·I E MisiutaA E Willing
Nov 22, 2020·Metabolic Brain Disease·Mojgan HamdamiMohammad Nasehi
Aug 30, 2000·Psychiatry Research·J C SoaresA G Mallinger
Dec 1, 1999·Biological Psychiatry·H K Manji, R H Lenox
Aug 10, 2002·Journal of Psychosomatic Research·Todd D Gould, Husseini K Manji
Mar 23, 2002·European Journal of Pharmacology·Alessandro SerrettiEnrico Smeraldi
Jul 25, 2003·Brain Research. Molecular Brain Research·Alon ShamirGalila Agam