Lithium-induced changes in plasma amino acid levels during treatment of affective disorders

Psychiatry Research
W P LeightonJ D Chanley

Abstract

Plasma amino acid (AA) profiles were determined in patients with bipolar affective disorders before and during treatment with lithium (Li) carbonate. After 90 days of Li intake, there were moderately (20-60%) but significantly decreased plasma levels of isoleucine, leucine, and valine. After 150 days of Li intake, the plasma lysine was also significantly decreased (12%). No significant changes in plasma levels were noted for any of the other 17 AAs that were studied. Since isoleucine, leucine, and valine are important competitors of tryptophan uptake at the blood-brain barrier, these observations suggest a possible mechanism for the therapeutic activity of Li, i.e., the enhancement of brain serotonin levels.

References

May 1, 1977·Journal of Neurochemistry·A YuwilerL Braun
Jan 1, 1979·Neuroscience·G E Fagg, J D Lane
Mar 1, 1979·Journal of Affective Disorders·S E MøllerP Honoré
Feb 1, 1978·Psychological Medicine·A Coppen, K Wood
Jan 1, 1978·Progress in Neuro-psychopharmacology·D L MurphyJ L Costa
Mar 1, 1978·Acta Psychiatrica Scandinavica·G d'EliaH Raotma
Jan 29, 1979·Life Sciences·D L Garver, J M Davis
Dec 1, 1979·Journal of Chromatography·W P LeightonJ D Chanley
Jun 1, 1978·Journal of Neurochemistry·J D Fernstrom, D V Faller
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·E B MillerP J Skripal
Jan 1, 1977·Journal of Neurochemistry·W M Pardridge, W H Oldendorf
Jan 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·P NiskanenJ Jääskeläinen
Aug 11, 1981·Molecular and Cellular Biochemistry·M J Brennan, R C Cantrill
Mar 1, 1982·Journal of Affective Disorders·P HonoréA Jørgensen
Jan 1, 1980·The Journal of Membrane Biology·B E Ehrlich, J M Diamond

❮ Previous
Next ❯

Citations

Dec 1, 1992·Neurochemistry International·A TakadaM Diksic
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·L HernandezB G Hoebel
Jan 1, 1986·General Pharmacology·M E Otero Losada, M C Rubio
May 5, 2009·Neuroscience Research·Junko KasuyaToshihiro Kitamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.