PMID: 7708Apr 1, 1976

Lithium-induced impairment of urine acidification

Kidney International
J M RoscoeB J Stinebaugh

Abstract

The purpose of this study was to clarify the means by which lithium induced a disorder of urine acidification. Rats infused with hydrochloric acid (1 mEq/kg) developed acute metabolic acidosis (blood Ph = 7.32; bicarbonate, 18 mEq/liter) with a urine pH of approximately 5.85. The addition of lithium chloride (4 mEq/kg i.p) caused an increase in the urine pH (6.38) and a further decrease in blood bicarbonate (11.0 mEq/liter). During bicarbonate loading, lithium caused the urine PCO2 to fall significantly (urine minus blood PCO2 decreased from 25.3 +/-2.8 To 14.4 +/- 2.3 mm Hg) These changes were not seen following equimolar i.p. administration of sodium chloride. Similarly, lithium administration depressed bicarbonate reabsorption by 11.1% (from 30.6 to 27.2muEq/ml of GFR) during alkali infusion, while saline caused only a 5% decrease (30.0 to 28.5muEq/ml of GFR). The combination of an increase in urine PCO2 in alkaline urine indicates that lithium produced a defect in distal nephron hydrogen ion secretion. The fall in bicarbonate reabsorption following lithium administration oculd be due to a mild hydrogen ion secretory defect located in the proximal tubule or a severe defect in the distal nephron.

References

May 1, 1972·The Journal of Clinical Investigation·I SingerJ B Puschett
Mar 1, 1973·Kidney International·I Singer, E A Franko
Aug 2, 1973·The New England Journal of Medicine·I Singer, D Rotenberg
Mar 1, 1974·The Journal of Clinical Investigation·M L HalperinB J Stinebaugh
Jan 1, 1969·Annual Review of Medicine·J Rodriguez-Soriano, C M Edelmann
Jan 1, 1971·Annual Review of Pharmacology·J M Davis, W E Fann
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Citations

Mar 12, 2009·Pflügers Archiv : European journal of physiology·Carsten A WagnerNilufar Mohebbi
Feb 1, 1996·Disease-a-month : DM·M E Laski, N A Kurtzman
Jul 1, 1976·The Journal of Clinical Investigation·R A GiammarcoB J Stinebaugh
Oct 1, 1977·The Journal of Clinical Investigation·J A ArrudaN A Kurtzman
Mar 1, 1982·Kidney International·D C BatlleN A Kurtzman
Nov 1, 1980·Kidney International·J B MyersC Ray
Jan 1, 1981·Kidney International·B J StinebaughM L Halperin
Dec 1, 1983·Kidney International·N A Kurtzman
Nov 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R BotonD C Batlle
Nov 28, 2017·Journal of Nephrology·Francesco TrepiccioneSebastian Frische
Jan 11, 2014·Journal of the American Society of Nephrology : JASN·Theun de GrootPeter M T Deen
Feb 27, 2016·F1000Research·Amy Quynh Trang PhamOrson W Moe
Jul 11, 2006·American Journal of Physiology. Renal Physiology·Joris H RobbenPeter M T Deen
Sep 28, 2019·Journal of the American Society of Nephrology : JASN·Theun de GrootRon Korstanje
Sep 1, 2000·American Journal of Physiology. Renal Physiology·T H KwonSøren Nielsen
Aug 1, 1979·Acta Psychiatrica Scandinavica·E T MellerupO J Rafaelsen
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Oct 22, 2002·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Aug 29, 2003·American Journal of Physiology. Renal Physiology·Young-Hee KimSøren Nielsen
Dec 17, 2014·Physiological Reports·I David WeinerRobert J Walker
Mar 1, 1978·The American Journal of Physiology·K LauM Goldberg
Mar 20, 1989·The Medical Journal of Australia·C R George

Related Concepts

Acid-Base Imbalance
Metabolic Acidosis
Renal Tubular Acidosis, Type II
Carbonic Acid Ions
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Kidney Tubules, Proximal
Lithium
Orthophosphate
Sodium Chloride, (24)NaCl

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