PMID: 7023348Jul 1, 1981Paper

Lithium nephrotoxicity: a review

Annals of Clinical and Laboratory Science
W Y ChanO M Rennert

Abstract

Lithium, a group I alkali metal, is widely used for treatment of manic-depressive psychosis. A number of toxic side effects have been reported, among which the most common ones are nephrogenic diabetes insipidus, distal tubular acidosis, and impairment of renal concentrating ability. The proposed mechanisms in the literature of these renal complications of lithium salt therapy are reviewed. None of the proposed mechanisms can be definitively established. Recently reported observations contradict the causative role of lithium in the pathogenesis of renal complications. More careful selection of control subjects is required for further investigation of the nephrotoxic effects of lithium.

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

The New Zealand Medical Journal
K J MacDonaldR R Bailey
Revista da Associação Médica Brasileira
Jobson Lopes de OliveiraElizabeth de Francesco Daher
Journal of Affective Disorders
John TredgetGeorge Kirov
Obstetrics and Gynecology
M S AngV M Parisi
© 2021 Meta ULC. All rights reserved