PMID: 9174239May 20, 1997Paper

Lithium-pilocarpine status epilepticus in the immature rabbit

Brain Research. Developmental Brain Research
Kerry W Thompson, C G Wasterlain

Abstract

Although status epilepticus in children is associated with neuronal pathologies, there are few developmental models of status epilepticus which produce damage in the immature brain. We have developed a new model of status epilepticus using systemically injected pilocarpine in immature rabbits pretreated with lithium. Injected animals demonstrated behavioral and electrographic seizures. Behavioral seizures were characterized by sustained or recurrent bouts of clonus in all limbs. The pilocarpine-induced seizures had a 40% mortality. All animals surviving the status epilepticus had hippocampal lesions when evaluated 48 h after the SE. Within the hippocampus, CA1 pyramidal cells were the most vulnerable cell population. Extrahippocampal damage was seen in the majority of animals. Our results show that severe seizures cause hippocampal lesions in the absence of hypoxemia and suggest that the presumed resistance of the immature brain to seizure-induced damage is not a general rule which can be applied to all models or species.

References

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Feb 18, 1998·Neuroscience·K ThompsonC Wasterlain

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Citations

Dec 8, 2010·Neurochemical Research·Claude G WasterlainJerome Niquet
Mar 5, 1999·Brain Research. Developmental Brain Research·J TowfighiR C Vannucci
Jun 16, 2007·Epilepsia·Morris H ScantleburySolomon L Moshé
Apr 11, 2006·Epilepsy Currents·Claude G Wasterlain
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hernan GonzalezAlistair J Gunn
Aug 9, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Linda K FriedmanRobert Keesey
Sep 8, 2004·Brain Research. Developmental Brain Research·Javad TowfighiRobert C Vannucci
Nov 29, 2005·Seizure : the Journal of the British Epilepsy Association·H LiuJ Kaur
Jun 14, 2008·Journal of Neuroscience Methods·Giulia CuriaMassimo Avoli
Nov 3, 2009·Neurobiology of Disease·Maria-Leonor Lopez-MerazJerome Niquet
Aug 24, 2007·Journal of Child Neurology·Raman Sankar, Jong M Rho
Oct 5, 2016·Experimental and Therapeutic Medicine·Liliana Carmona-AparicioNoemí Cárdenas-Rodríguez
Dec 20, 2018·Epilepsia Open·Kerry W ThompsonClaude G Wasterlain

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