Lithium prescribing during pregnancy: a UK primary care database study

PloS One
Rachel L McCreaIrene Petersen

Abstract

Women taking lithium must decide whether to continue the medication if they conceive or plan to conceive. Little is known about the extent of prescribing of lithium during pregnancy. To determine: 1) the prevalence of lithium prescribing during pregnancy and 2) to assess whether pregnancy is associated with discontinuation of lithium. First, we identified women receiving any lithium prescriptions before and during pregnancy using The Health Improvement Network (THIN) primary care database. Subsequently, we used a Kaplan-Meier plot to compare time to last prescription in women prescribed lithium continuously three months before pregnancy and a comparison group of non-pregnant women. Finally, we described the characteristics of the women prescribed lithium in pregnancy. Very few women were prescribed lithium during pregnancy; out of 458,761 pregnancies, we identified 47 (0.01%) in which lithium was prescribed after the 6th week of pregnancy (when the pregnancy was likely to be known). In our study of discontinuation, we found pregnant women were more likely to stop lithium than those who were not pregnant. Of the 52 women who were being continuously prescribed lithium three months before pregnancy, only 17 (33%) continued receivi...Continue Reading

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Citations

Sep 21, 2015·Early Human Development·Hind KhalifehLouise M Howard
May 27, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Christine LeongAlan Katz
Jun 16, 2017·Journal of Psychosomatic Obstetrics and Gynaecology·Jacqueline FrayneHelena Liira
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May 28, 2020·Frontiers in Psychiatry·Constantin VolkmannStephan Köhler
Dec 4, 2020·General Hospital Psychiatry·Amelia C WendtAmritha Bhat

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