Lithium stimulation of diffusion chamber colony growth is mediated by factors other than colony-stimulating factor

International Journal of Cell Cloning
M A DoukasC Gass

Abstract

Lithium is a recognized, potent stimulator of granulopoiesis. The present study used the model of clonal growth of granulopoietic precursors in diffusion chambers to investigate the relevance of certain colony-stimulating factors to lithium stimulation in vivo. In this system, lithium stimulation of granulopoiesis could not be attributed to changes in serum or chamber fluid colony-stimulating factor levels. Antibody to colony-stimulating factor-1 administered during culture markedly reduced morphologic expression of colonies in control and lithium-pretreated host mice, yet subculture of chamber contents revealed that lithium stimulation of a granulopoietic progenitor, perhaps of primitive potentiality, had nevertheless occurred. Therefore, we hypothesize that lithium acts in an indirect, hormonal fashion and that these colony-stimulating factors, while necessary for morphologic expression, play no role in the stimulatory effect. This hypothesis raises the possibility that lithium in combination with recombinant colony-stimulating factors may result in clinically effective synergistic stimulation of granulopoiesis.

References

Mar 1, 1985·International Journal of Cell Cloning·G R JohnsonN A Nicola
Jan 31, 1980·The New England Journal of Medicine·G H LymanD Preston
May 1, 1981·Biulleten' eksperimental'noĭ biologii i meditsiny·S B Stepanova, N A Fedorov
Feb 1, 1984·British Journal of Haematology·R A Joyce
Jan 1, 1980·Advances in Experimental Medicine and Biology·A R Turner, M J Allalunis
Feb 1, 1980·The Journal of Clinical Investigation·E Niskanen, M J Cline

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Citations

Jan 1, 2009·Expert Opinion on Drug Discovery·Moorthy Ss PalankiGlenn Noronha
Feb 29, 2016·Pharmacological Reports : PR·Ewa Ferensztajn-Rochowiak, Janusz K Rybakowski
Nov 1, 1989·International Journal of Cell Cloning·E NiskanenM Symann
Nov 30, 2011·Current Opinion in Hematology·Mario Petrini, Antonio Azzarà

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