Live birth rate after human chorionic gonadotropin priming in vitro maturation in women with polycystic ovary syndrome

Journal of Ovarian Research
V N A HoL N Vuong

Abstract

In vitro maturation (IVM) has some advantages over conventional in vitro fertilization (IVF), particularly in polycystic ovary syndrome (PCOS) where the risk of ovarian hyperstimulation is high. We studied the live birth rate in a large series of PCOS women undergoing human chorionic gonadotropin (hCG)-priming IVM. This retrospective study included women with PCOS aged 18-42 years undergoing IVM with hCG priming. We reported live birth rate after the first embryo transfer and cumulative live birth rate from embryos obtained in the IVM cycle. We also performed logistic regression to assess which factors predicted number of oocytes and live birth. We included 921 women (age 28.9±3.5 years, body mass index 21.8±3.1 kg/m2, infertility duration 3.7±2.6 years, 81% primary infertility, 88% first IVF attempt, 94% ovulation induction failure). Live birth rate after the first embryo transfer was 31.7%, with a cumulative live birth rate from the cycle of 33.7%. High anti-Müllerian hormone levels predicted a high number of oocytes and a high oocyte maturation rate while the opposite was the case when luteinizing hormone levels were high. In women with PCOS, hCG priming IVM was feasible and resulted in acceptable live birth rates.

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Citations

Nov 2, 2019·Journal of Assisted Reproduction and Genetics·Y ZhaoR B Gilchrist
Jan 7, 2020·Journal of Assisted Reproduction and Genetics·Lan N VuongJohan Smitz
Dec 15, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·G E Crawford, W L Ledger
Nov 3, 2020·Reproductive Biomedicine Online·Sanne C BraamLan N Vuong
Dec 29, 2020·Fertility and Sterility·UNKNOWN Practice Committees of the American Society for Reproductive Medicine, the Society of Reproductive Biologists and Technologi
Jun 3, 2021·Reproductive Sciences·Xueqi GongYiqing Zhao
Jul 5, 2021·Journal of Assisted Reproduction and Genetics·Michel De VosRobert B Gilchrist

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