Live birth rates after MESA or TESE in men with obstructive azoospermia: is there a difference?

Human Reproduction
Madelon van WelyS J Silber

Abstract

How do live birth rates compare after intracytoplasmic sperm injection (ICSI) for men with obstructive azoospermia when using sperm derived from testicular sperm extraction (TESE) versus microsurgical epididymal sperm aspiration (MESA)? Our study suggests that proximal epididymal sperm (from MESA) result in higher live birth rates as compared with testicular sperm (from TESE) in couples where the man has obstructive azoospermia due to congenital bilateral absence of the vas deferens (CBAVD) or vasectomy. For couples with obstructive azoospermia, MESA (epididymal sperm) and TESE (testicular sperm) have generally been assumed to be equivalent for use in ICSI. But this assumption has never been confirmed, and this view has important clinical and basic scientific consequences. This was a retrospective study of a consecutive cohort of 374 men with obstructive azoospermia and normal spermatogenesis, who underwent IVF and ICSI using either epididymal sperm or testicular sperm in the period 2000-2009. The study included men undergoing MESA or TESE at St. Luke's Hospital for obstructive azoospermia due to CBAVD or vasectomy. A total of 280 couples underwent MESA and 94 underwent TESE with ICSI. The live birth rate was 39% after MESA-ICS...Continue Reading

References

Aug 1, 1978·The American Journal of Anatomy·J M Bedford
Nov 1, 1978·The Journal of Endocrinology·M A de LarminatJ A Blaquier
Dec 27, 1990·The New England Journal of Medicine·S J SilberR H Asch
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H SchattenC Simerly
Mar 1, 1988·Biology of Reproduction·M K Holland, M C Orgebin-Crist
Sep 1, 1987·Gamete Research·D M Phillips, J M Bedford
Dec 14, 1985·British Medical Journal·M G HullK M Desai
Sep 1, 1972·Journal of Reproduction and Fertility·A H Horan, J M Bedford
Sep 1, 1983·Endocrinology·J G Tezón, J A Blaquier
Jan 1, 1982·Journal of Reproduction and Fertility·F M González EcheverríaJ A Blaquier
Dec 1, 1982·International Journal of Andrology·J C GarberiJ A Blaquier
Nov 4, 2000·Biochimica Et Biophysica Acta·D E OngM C Orgebin-Crist
Jan 11, 2000·Clinical Obstetrics and Gynecology·S J Silber
Jan 14, 2003·Fertility and Sterility·Sherman SilberSantiago Munné
Nov 7, 2003·The Journal of Urology·Jonathan P Jarow
Jun 12, 2004·Biological Reviews of the Cambridge Philosophical Society·J Michael Bedford
Oct 13, 2004·Journal of Andrology·Sherman J Silber, H Edward Grotjan
Jun 17, 2008·Human Reproduction·R LeeP N Schlegel
Jan 22, 2011·Der Urologe. Ausg. A·T DiemerW Weidner

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Citations

Apr 28, 2018·Journal of Assisted Reproduction and Genetics·Jennifer F KawwassDmitry M Kissin
Feb 23, 2018·Journal of Assisted Reproduction and Genetics·P ComizzoliL K McGinnis
May 5, 2018·Human Reproduction Update·Jitske EliveldAns M M van Pelt
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
Jan 27, 2018·Reproductive Medicine and Biology·Hatsuki HibiYoshimasa Asada
Jul 9, 2021·Fertility and Sterility·Lauren M Kendall RauchfussChandra C Shenoy

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