Live-birth rates in very poor prognosis patients, who are defined as poor responders under the Bologna criteria, with nonelective single embryo, two-embryo, and three or more embryos transferred

Fertility and Sterility
Norbert GleicherVitaly A Kushnir

Abstract

To determine live-birth rates (LBRs) at various ages in very poor prognosis patients, who are defined as poor responders under the Bologna criteria. Retrospective cohort study. Academically affiliated private fertility center. Among 483 patients, who under the Bologna criteria (three or fewer oocytes, >40 years of age, and/or antimüllerian hormone [AMH] <1.1 ng/mL [2/3 criteria minimum]) were poor responders, 278 (381 fresh IVF cycles) qualified for the study because they had at least one embryo on day 3 for transfer. IVF cycles in women with low functional ovarian reserve, involving androgen and CoQ10 supplementation and ovarian stimulation with daily gonadotropin dosages of 300-450 IU of FSH and 150 IU of hMG in microdose agonist cycles. Age-specific LBRs per ET. Ages did not differ between nonelective (ne) single ET (SET), ne2-ET, and ne ≥ 3-ET cycles (41.3 ± 3.9, 41.7 ± 3.1, and 42.4 ± 2.1 years, respectively). Patients with neSETs demonstrated significantly lower AMH and higher FSH levels and required higher gonadotropin dosages than ne2-ET and ne ≥ 3-ET patients. LBRs declined with age. Above age 42, three or more embryos are required to achieve reasonable LBRs and two or more to avoid futility under American Society for ...Continue Reading

References

Jun 16, 2004·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·R OrvietoB Fisch
Jan 2, 2007·Fertility and Sterility·Steven D SpandorferZev Rosenwaks
Dec 8, 2007·Journal of Assisted Reproduction and Genetics·Norbert GleicherDavid Barad
Dec 25, 2007·BMC Health Services Research·Reija KlemettiElina Hemminki
Nov 17, 2009·Reproductive Biomedicine Online·Ariel HourvitzJacob Levron
Apr 21, 2011·Human Reproduction·A P FerrarettiUNKNOWN ESHRE working group on Poor Ovarian Response Definition
May 3, 2011·Human Reproduction·Andrea WeghoferNorbert Gleicher
Apr 28, 2012·Fertility and Sterility·UNKNOWN Ethics Committee of American Society for Reproductive Medicine
Jun 13, 2013·Fertility and Sterility·Vitaly A KushnirNorbert Gleicher
Aug 10, 2013·Fertility and Sterility·Dmitry M KissinSheree L Boulet
Jul 12, 2014·Reproductive Biology and Endocrinology : RB&E·Norbert GleicherDavid H Barad
Jul 30, 2014·Human Reproduction·M S KupkaUNKNOWN European IVF-Monitoring Consortium, for the European Society of Human Reproduction and Embryology
Mar 17, 2015·Reproductive Biomedicine Online·Jiřina KocourkováTomáš Kučera
May 6, 2015·Nature Reviews. Endocrinology·Aya Shohat-TalNorbert Gleicher
Aug 13, 2015·The Journal of Endocrinology·Yan-Guang WuNorbert Gleicher

❮ Previous
Next ❯

Citations

Mar 10, 2016·American Journal of Reproductive Immunology : AJRI·Vitaly A KushnirNorbert Gleicher
May 8, 2016·The Journal of Endocrinology·Norbert GleicherDavid H Barad
Mar 8, 2017·Reproductive Sciences·Vitaly A KushnirNorbert Gleicher
Jun 25, 2016·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Laura M MillerNeil P Johnson
Jun 2, 2018·Minerva ginecologica·Paolo G ArtiniVito Cela
Apr 30, 2017·Journal of Assisted Reproduction and Genetics·Heather HippDenise Jamieson
Jan 11, 2017·Reproductive Biology and Endocrinology : RB&E·Vitaly A KushnirNorbert Gleicher
Jun 24, 2017·Journal of Assisted Reproduction and Genetics·Vitaly A KushnirNorbert Gleicher
Oct 1, 2018·Journal of Assisted Reproduction and Genetics·Maria Eduarda Bonavides AmaralEdmund Chada Baracat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
H PinkasB Fisch
Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
Gustavo Salata RomãoMaria Albina Verceze Bortolieiro
© 2021 Meta ULC. All rights reserved