Live free or die: tales of homeless (cells) in cancer.

The American Journal of Pathology
Craig HorbinskiNatasha Kyprianou

Abstract

Anoikis, programed cell death that occurs on cell detachment from the extracellular matrix, thus disrupting integrin-ligand interactions, is a critical mechanism in preventing ectopic cell growth or attachment to an inappropriate matrix. Anoikis prevents shed epithelial cells from colonizing elsewhere and is thus essential for maintaining tissue organization. Lack of integrin ligation leads to decreased focal adhesion kinase and integrin-linked kinase activity, which impairs downstream survival signaling. Consequently, targeting tumor cell survival by triggering anoikis provides a unique molecular basis for novel therapeutic targeting of tumors before initiation of metastasis. The two major cell death pathways involved in anoikis signaling are apoptosis and autophagy; growing evidence suggests an extensive cross-talk between the two killing modes as well as context-dependent cooperation and antagonism. This review discusses the functional integration between the two modes of cell death converging at anoikis, including key molecules of interaction such as Beclin 1, reactive oxygen species, extracellular signal-related kinase, and death-associated protein kinase. The involvement of other apoptotic effectors such as Bcl-2, p53, an...Continue Reading

References

Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Aug 1, 1996·The Journal of Cell Biology·S M FrischP Y Chan-Hui
Jan 9, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Aug 24, 1999·Circulation Research·A E LiT Finkel
Jul 21, 2001·Molecular Cell·J YuB Vogelstein
Oct 9, 2002·The Journal of Cell Biology·Won-Jing WangRuey-Hwa Chen
Dec 18, 2002·Annals of the New York Academy of Sciences·Wilfrid RulUrsula Hibner
Jul 5, 2003·Nature Cell Biology·Mauricio J ReginatoJoan S Brugge
Nov 26, 2003·The Journal of Clinical Investigation·Xueping QuBeth Levine
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Mar 3, 2004·Molecular Interventions·Michelle M HillSeamus J Martin
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kenna R MillsJoan S Brugge
May 4, 2004·Molecular and Cellular Biology·Elena KurenovaWilliam G Cance
Sep 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Philippe P RouxJohn Blenis
Dec 14, 2004·Free Radical Biology & Medicine·Craig Horbinski, Charleen T Chu
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zhaohui FengShengkan Jin
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Oct 26, 2005·Cell Death and Differentiation·N Mizushima
Jun 8, 2006·Annual Review of Biochemistry·Shani Bialik, Adi Kimchi
Jul 29, 2006·Autophagy·Jayanta DebnathGuido Kroemer
Mar 31, 2007·Nature Methods·Genee Y LeeMina J Bissell
May 19, 2007·Genes & Development·Robin MathewEileen White
Jul 3, 2007·Free Radical Biology & Medicine·Scott M KulichCharleen T Chu
Oct 12, 2007·Biochimie·Sophie PattingrePatrice Codogno
Feb 5, 2008·Cancer Research·Luciana M LaguingeJ Milburn Jessup
Feb 9, 2008·Cell Death and Differentiation·E GiannoniP Chiarugi
May 6, 2008·Nature Cell Biology·Ezgi TasdemirGuido Kroemer
May 17, 2008·Cancer Research·Tamer T OnderRobert A Weinberg
Jun 27, 2008·Cancer Letters·Craig D SimpsonAaron D Schimmer
Aug 19, 2008·Biochemical Pharmacology·Paola Chiarugi, Elisa Giannoni
Nov 8, 2008·Cellular and Molecular Life Sciences : CMLS·M Gudur Valmiki, J W Ramos
Dec 31, 2008·Autophagy·Angeles Rodríguez-HernándezJosé A Sánchez-Alcázar
Jan 24, 2009·Apoptosis : an International Journal on Programmed Cell Death·Ausra SasnauskieneVida Kirveliene

❮ Previous
Next ❯

Citations

Jun 28, 2011·Biochemical Pharmacology·Annick NotteCarine Michiels
Oct 11, 2011·Molecular Pharmaceutics·Jae Youn HwangLali K Medina-Kauwe
Oct 24, 2013·Nature Communications·Yongqing LiuDouglas C Dean
Aug 20, 2011·Genes & Development·Alexandra R GrassianJoan S Brugge
Jan 25, 2012·International Journal of Cell Biology·Chee Wai WongDeirdre R Coombe
Dec 7, 2013·Cancer Chemotherapy and Pharmacology·Le-chen LiYan-bo Li
Jan 25, 2014·Cell Death & Disease·M SilginerP Roth
May 9, 2012·Chemotherapy Research and Practice·Fawzi Aoudjit, Kristiina Vuori
Feb 6, 2013·The Journal of Biological Chemistry·Zhiyou Fang, Elizabeth J Luna
Nov 5, 2014·Tissue Engineering. Part B, Reviews·Zijun Zhang
May 15, 2012·Seminars in Cell & Developmental Biology·Cassandra L BuchheitZachary T Schafer
Jul 9, 2013·Biochimica Et Biophysica Acta·Paolo PaoliPaola Chiarugi
Jun 8, 2013·International Journal of Molecular Sciences·Elio ZiparoClaudia Giampietri
Jan 18, 2018·The Journal of Biological Chemistry·Mark A Hawk, Zachary T Schafer
Sep 29, 2011·The Journal of Pathology·M L TaddeiP Chiarugi
Apr 26, 2019·International Journal of Cancer. Journal International Du Cancer·Ruoxiang WangLeland W K Chung
Jul 2, 2019·Chinese Medical Journal·Ying Jin, Ji-Liang Li
Aug 22, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jie YangZhenyi Ma
Jul 16, 2020·Journal of Hematology & Oncology·Dusten Unruh, Craig Horbinski
Jan 20, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Masashi Takao, Kazuo Takeda
Jul 2, 2020·Frontiers of Medicine·Solmaz Ohadian Moghadam, Seyed Ali Momeni
Nov 12, 2020·Cancers·Andrea AngiusMaria Rosaria De Miglio
May 8, 2014·Molecular Cancer Research : MCR·Kelsey J WeigelZachary T Schafer
Oct 30, 2020·Frontiers in Oncology·Rodolfo Chavez-DominguezDolores Aguilar-Cazares

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.