Live Liver Donors: Is Right Still Right?

World Journal of Surgery
Ashwin RammohanMohamed Rela

Abstract

Conventional wisdom dictates that a larger hepatectomy is more prone to complications. Consequently, with the donor safety as paramount, the transplant community has intuitively been proponents of left lobe donation in live donor liver transplantation (LDLT), thereby satisfying the tenet of double equipoise. More recently some data suggest that this may not always be the case, especially in established centres. Our aim was to compare right and left lobe donor outcomes in LDLT from a centre with cumulative experience. Review of a prospectively collected database of right and left lobe liver donors operated between August 2009 and July 2017 was performed. Their preoperative demographics, operative and post-operative outcomes were compared. Of 904 liver transplantations, 458 were right lobe donors [379 without middle hepatic vein (MHV), 79 with MHV] and 58 left lobe donors. There was a significant difference in GRWR and functional liver remnant between the right and left lobe donors (1.27 ± 0.45 vs. 1.03 ± 0.28 p = 0.004, and 63.2 ± 7.9 vs. 37.7 ± 16.3, respectively, p value). The end portal pressure (7 vs. 8 mmHg p = <0.001), peak bilirubin (1.6 ± 0.8 vs. 2.9 ± 1.5 p = <0.001) and day 5 bilirubin (0.8 ± 0.3 vs. 1.4 ± 0.9 p = <0.0...Continue Reading

References

Aug 26, 1989·Lancet·S RaiaS Mies
May 25, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shin HwangGi-Won Song
Jul 18, 2008·Transplantation Reviews·Charles M Miller
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C Burcin TanerYaman Tokat
Feb 10, 2009·Transplantation·Akinobu TaketomiYoshihiko Maehara
Jul 9, 2009·Transplantation·Yasuhiko HashikuraUNKNOWN Japanese Liver Transplantation Society
Feb 13, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S C ChanS T Fan
Nov 19, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Klaus SteinbrückLúcio Filgueiras Pacheco-Moreira
Aug 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Trevor W ReichmanDavid R Grant
Feb 18, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M M AbecassisUNKNOWN A2ALL Study Group
Apr 14, 2012·The Mount Sinai Journal of Medicine, New York·Charles M MillerTeresa Diago Uso
Jun 8, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Reza F SaidiAdel Bozorgzadeh
Nov 23, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yee Lee CheahElizabeth A Pomfret
Mar 1, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Garrett R RollJohn Paul Roberts
Sep 17, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mettu Srinivas ReddyMohamed Rela
Dec 7, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G R Roll, J P Roberts
Jan 30, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H UchiyamaY Maehara
Aug 2, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Junji IwasakiShinji Uemoto
Oct 1, 2008·Medical Journal, Armed Forces India·S P SinghM K Garg
Nov 14, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Sanjay GojaArvinder Singh Soin

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Citations

Aug 7, 2021·World Journal of Gastrointestinal Surgery·Ashwin Rammohan, Mohamed Rela
Aug 13, 2021·Pediatric Transplantation·Mohamed RelaAshwin Rammohan

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