Live predators, robots, and computer-animated images elicit differential avoidance responses in zebrafish

Zebrafish
Fabrizio LaduMaurizio Porfiri

Abstract

Emotional disturbances constitute a major health issue affecting a considerable portion of the population in western countries. In this context, animal models offer a relevant tool to address the underlying biological determinants and to screen novel therapeutic strategies. While rodents have traditionally constituted the species of choice, zebrafish are now becoming a viable alternative. As zebrafish gain momentum in biomedical sciences, considerable efforts are being devoted to developing high-throughput behavioral tests. Here, we present a comparative study of zebrafish behavioral response to fear-evoking stimuli offered via three alternative methodologies. Specifically, in a binary-choice test, we exposed zebrafish to an allopatric predator Astronotus ocellatus, presented in the form of a live subject, a robotic replica, and a computer-animated image. The robot's design and operation were inspired by the morphology and tail-beat motion of its live counterpart, thereby offering a consistent three-dimensional stimulus to focal fish. The computer-animated image was also designed after the live subject to replicate its appearance. We observed that differently from computer-animated images, both the live predator and its robotic...Continue Reading

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Citations

Apr 25, 2015·Behavioural Brain Research·Fabrizio LaduMaurizio Porfiri
Oct 30, 2016·Alcoholism, Clinical and Experimental Research·Diane SeguinRobert Gerlai
Jan 11, 2017·Scientific Reports·Violet MwaffoMaurizio Porfiri
Jan 14, 2018·Scientific Reports·Changsu KimMaurizio Porfiri
Feb 20, 2016·Bioinspiration & Biomimetics·Tiziana BartoliniMaurizio Porfiri
Sep 28, 2017·Bioinspiration & Biomimetics·Leo CazenilleJosé Halloy
Sep 12, 2019·Journal of the Royal Society, Interface·Giovanni PolverinoMaurizio Porfiri
Feb 6, 2016·Bioinspiration & Biomimetics·L JollyE de Margerie
Nov 18, 2016·Royal Society Open Science·Tommaso RubertoMaurizio Porfiri
Aug 3, 2017·Chaos·Daniele NeriMaurizio Porfiri
Nov 16, 2018·Biological cybernetics·Donato RomanoCesare Stefanini
Feb 24, 2017·Journal of the Experimental Analysis of Behavior·Tommaso RubertoMaurizio Porfiri
Mar 2, 2018·Current Zoology·Robert Gerlai
Dec 29, 2018·Journal of the Experimental Analysis of Behavior·Toshikazu KurodaChristopher A Podlesnik
Dec 26, 2019·PeerJ·Mukta WatveBarbara Taborsky
Aug 12, 2020·Lab Animal·Simone MacrìMaurizio Porfiri
May 31, 2019·Frontiers in Robotics and AI·Chiara SpinelloMaurizio Porfiri
Jan 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise E MüllerDenis B Rosemberg
Nov 15, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mert KarakayaMaurizio Porfiri
Jul 18, 2021·Biological cybernetics·Alexander A BrownBrent A Utter

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