Live subgroup B respiratory syncytial virus vaccines that are attenuated, genetically stable, and immunogenic in rodents and nonhuman primates

The Journal of Infectious Diseases
J E CroweB R Murphy

Abstract

Optimal immunization of neonates against disease caused by respiratory syncytial virus (RSV) probably will require multiple doses of a vaccine containing viruses of both subgroups A and B. Live subgroup B RSV mutants were generated containing multiple attenuating mutations, ts (temperature-sensitive) and non-ts (host range), that were introduced by prolonged passage in cell culture or by chemical mutagenesis. The cold-passaged (cp)-52 mutant was restricted in replication compared to wild type virus in rodents and nonhuman primates. In addition, the attenuation phenotype of cp-52 was stable after prolonged replication in immunosuppressed rodents. One or two ts mutations were then introduced into the cp-52 mutant to generate additional candidate vaccine strains that were more attenuated in vivo than the cp-52 parental virus. Tests in humans are being done to determine if one or more of the RSV B-1 mutants exhibit a satisfactory balance between attenuation and immunogenicity.

Citations

Jun 22, 2002·Antiviral Research·Vladimir RazinkovGirija Krishnamurthy
Feb 11, 2000·Antiviral Research·J Treanor, A Falsey
Aug 26, 1998·Vaccine·J EnglundP A Piedra
Sep 2, 2011·The Journal of Infectious Diseases·Fu-Shi QuanRichard W Compans
Jan 26, 2007·Journal of the Royal Society, Interface·David FouchetDominique Pontier
Jan 11, 2000·Clinical Microbiology Reviews·W M Sullender
Nov 5, 1999·The Journal of Pediatrics·C G Prober, W M Sullender
Sep 15, 1999·Lancet·E A Simoes
Apr 30, 2003·Antiviral Chemistry & Chemotherapy·Paul F Torrence, Linda D Powell
Apr 13, 2000·Pediatric Clinics of North America·F M Munoz, J A Englund
May 4, 2004·Journal of Medical Virology·Matthew B ElliottGerald E Hancock
Jun 4, 2011·Eye·M R RazeghinejadL J Katz
Jan 30, 2018·Reviews in Medical Virology·Krisna N A PangestiGrant A Hill-Cawthorne
Oct 28, 2019·Frontiers in Immunology·Lydia J AthertonRalph A Tripp
May 21, 2021·Emerging Infectious Diseases·Vahid SalimiUrsula J Buchholz
Jul 1, 1998·Seminars in Pediatric Infectious Diseases·Kelly J Henrickson
May 26, 2009·New Biotechnology·Debprasad ChattopadhyayMahmud Tareq Hassan Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.