PMID: 11921743Mar 30, 2002Paper

Livedo reticularis in patients with systemic lupus erythematosis and its association with anticardiolipin antibodies

Investigación clínica
Zahira OstosHebert Espig

Abstract

With the purpose of determining whether a relationship exists between Livedo Reticularis (LR) and anticardiolipine antibodies (ACA) in patients with Systemic Lupus Erithemathosus (SLE), a clinical prospective and descriptive study was carried out on 17 female lupus patients with LR, aged 15-46, from the Immunology and Dermatology outpatient clinic of the Enrique Tejera Hospital Compound in Valencia, Venezuela, during 1998. A complete clinical evaluation of each patient was done, from which a diagnosis of LR was made. This was categorized as mild, moderate or severe (Weinstein and col. criteria), depending on the severity of the lesions. Immunoenzymatic techniques were used to determine ACA Ig or IgM. The study followed the Guidelines of Good Practices in Clinical Research, and a signed informed consent was obtained from each patient. The average age of the studied patients was 28.5 +/- 10.9 years; 52.9% of them presented serum levels of ACA IgG above normal. In all cases, levels of ACA IgM were within normal limits (4.41 +/- 2.63 U/mL. Range: 0.51-9.53). All patients with mild LR had normal levels of ACA IgG, and 83.3% and 80% of those in the Moderate and Severe categories, respectively, had high levels of ACA IgG (> or = 10 U/...Continue Reading

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