Livedoid vasculopathy: clinical features and treatment in 24 Chinese patients

Acta Dermato-venereologica
Suiying FengChanggeng Shao

Abstract

Livedo vasculopathy (LV) is a chronic cutaneous disorder characterised by recurrent, painful ulceration ending in stellate scars. We have conducted a retrospective study of clinical features and treatment response of LV in 24 Chinese patients. LV occurred more frequently in women (male:female ratio  1:3). The peak age at onset of disease ranged from 14 to 20 years, younger than previously published data. 87.5% of the patients (21/24) showed significant summer exacerbation with ulcer formation. Out of 24 patients tested, 14 (58.3%) had positive antiphospholipid antibodies. Ten out of 14 patients (71.4%) were tested to be hypersensitive to multivalent insect antigens. Combinative anti-inflammatory therapy with steroids, tetracycline and Tripterygium glycosides plus antiplatelet/profibrinolytic drugs promoted quick healing of ulcer and reduce recurrence. The younger age of disease presentation and significant summer exacerbation are 2 novel clinical features observed in this study. These findings suggest that apart from procoagulation other risk factors may contribute significantly to the pathogenesis of LV. Although antiplatelet/profibrinolytic drugs are deemed as a first line therapy for LV, anti-inflammatory medications such as...Continue Reading

Citations

Mar 3, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·R RennerC Erfurt-Berge
Apr 23, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·C WeishauptT Goerge
Jan 24, 2020·Advances in Skin & Wound Care·Asfandyar MuftiAfsaneh Alavi
Apr 18, 2018·International Journal of Dermatology·Gabriela Franco MarquesMaría Salomé Cajas García
Nov 7, 2019·Case Reports in Dermatological Medicine·John R EdministerLorie D Gottwald
Oct 13, 2020·International Wound Journal·Yimeng Gao, Hongzhong Jin
Sep 29, 2020·Clinical and Experimental Dermatology·S NuttawongC Rujitharanawong
Nov 22, 2020·Dermatologic Therapy·Chuda RujitharanawongSasipha Nuttawong
Mar 10, 2021·International Wound Journal·Yimeng Gao, Hongzhong Jin
Aug 21, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·Y Gao, H Jin

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