PMID: 8586769Jun 1, 1995Paper

Liver and biliary tract changes and injury associated with total parenteral nutrition: pathogenesis and prevention

Journal of the American College of Nutrition
E R Briones, F L Iber

Abstract

Total parenteral nutrition (TPN), now widely used, is successful in preventing and reversing malnutrition in individuals with various diseases and conditions. However, hepatic and biliary complications of TPN are encountered in both adult and pediatric patients. Certain complications, such as sepsis and TPN-associated cholestasis, occur more frequently in very young infants. Continuing problems commonly seen in adults are steatosis and steatonecrosis. Reasons for the development of these complications are multifactorial. Etiologies of hepatic complications, especially the role of deficiency/excess of nutrients in the pathogenesis of hepatobiliary disorders, are summarized. Complications caused by the duration of TPN are discussed with emphasis on prevention and management. Evidence now suggests that prompt enteral feeding, even in minimal amounts, may prevent many of the metabolic complications associated with TPN. TPN should be used only in amounts meeting needs and for a duration essential to survival.

References

Jun 1, 1979·JAMA : the Journal of the American Medical Association·K D LindorM A Hirschkorn
Nov 1, 1979·American Journal of Surgery·I L MacGregorL W Way
Apr 1, 1978·Archives of Surgery·G F SheldonR Sanders
Mar 1, 1975·The American Journal of Clinical Nutrition·T J Richardson, D Sgoutas
Jan 1, 1976·Journal of Clinical Pathology·J G Sissons
Oct 1, 1992·The Journal of Surgical Research·K NakanoT Yamasaki
Sep 1, 1992·Journal of Hepatology·A ThörneS Eriksson
Sep 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·E HolmeI Nordin
Feb 1, 1992·Metabolism: Clinical and Experimental·A WennbergK Lundholm
Nov 1, 1991·The Journal of Burn Care & Rehabilitation·R Y FlemingJ P Heggers
Jan 1, 1991·Annales Françaises D'anesthèsie Et De Rèanimation·M RaucoulesD Grimaud
Mar 1, 1991·The Journal of Trauma·M JeevanandamW R Schiller
Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·S ReifT Rossi
Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·P J ClarkeM G Kettlewell
Mar 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·M NakagawaM Yamamoto
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·F GuertinB Tuchweber
Aug 1, 1991·Journal of Pediatric Surgery·S KatzJ L Grosfeld
Jun 1, 1990·Journal of Pediatric Surgery·A KubotaY Takagi
Jun 1, 1990·Journal of Pediatric Surgery·G F WhalenJ Folkman
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberM A Leo
Mar 1, 1989·Archives of Surgery·V Cortes, L D Nelson
Jul 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·C DolzM A Gassull
Oct 1, 1989·The American Journal of Clinical Nutrition·J ArnoldM H Irving
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·R A Drongowski, A G Coran
Nov 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·S G SpurrN R Mehta
Jan 1, 1989·Journal of Perinatal Medicine·I AradP Lebensart
Jan 1, 1989·Annual Review of Nutrition·S A Goldstein, D H Elwyn
May 28, 1988·Lancet·J B SchwartzA Ramos

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Citations

Mar 24, 2007·Digestive Diseases and Sciences·Mark DeLeggeNicole M Moore
Apr 9, 2001·Clinics in Liver Disease·S I StrasserG B McDonald
May 31, 2001·British Journal of Haematology·C LiatsosA K Burroughs
Sep 3, 2011·Clinics in Colon and Rectal Surgery·Lara J WilliamsRobin P Boushey
Jan 2, 2007·Journal of Clinical Gastroenterology·Evangelos P MisiakosTheodore Liakakos
Feb 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Teodoro Grau, Alfonso Bonet
Feb 12, 1998·Archives of Disease in Childhood. Fetal and Neonatal Edition·A LanderI W Booth
Jan 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Teodoro GrauUNKNOWN Working Group on Nutrition and Metabolism of the Spanish Society of Critical Care
Dec 7, 2010·Journal of Pediatric Surgery·Wei HaoKenneth K Y Wong
Nov 30, 2010·Clinics in Liver Disease·Jason B Samarasena, Ke-Qin Hu
Feb 13, 2009·Medicina clínica·Luis ServiaAngel Rodríguez-Pozo
Jul 22, 2008·American Journal of Surgery·Ismail BilgicM Mahir Ozmen
Mar 6, 2007·Journal of Pediatric Surgery·Akshay PratapShailesh Adhikary
Jun 15, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Peggy A WuWilliam E Berquist
Feb 14, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gary R MartinDavid L Sigalet
Nov 18, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Eduardo ZambranoMiguel Reyes-Múgica
Apr 28, 2007·JPEN. Journal of Parenteral and Enteral Nutrition·Li HongWei Cai
Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Maitreyi Raman, Johane P Allard
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·A SevetteR C Smith
Sep 22, 2006·The Journal of Nutrition·Hui WangBoris Yoffe
Oct 6, 2017·Nutrition Journal·Jose J Arenas VillafrancaJimena Abilés

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