Liver and muscle in morbid obesity: the interplay of fatty liver and insulin resistance.

PloS One
Mariana Verdelho MachadoHelena Cortez-Pinto

Abstract

Nonalcoholic fatty liver disease (NAFLD) can be seen as a manifestation of overnutrition. The muscle is a central player in the adaptation to energy overload, and there is an association between fatty-muscle and -liver. We aimed to correlate muscle morphology, mitochondrial function and insulin signaling with NAFLD severity in morbid obese patients. Liver and deltoid muscle biopsies were collected during bariatric surgery in NAFLD patients. NAFLD Activity Score and Younossi's classification for nonalcoholic steatohepatitis (NASH) were applied to liver histology. Muscle evaluation included morphology studies, respiratory chain complex I to IV enzyme assays, and analysis of the insulin signaling cascade. A healthy lean control group was included for muscle morphology and mitochondrial function analyses. Fifty one NAFLD patients were included of whom 43% had NASH. Intramyocellular lipids (IMCL) were associated with the presence of NASH (OR 12.5, p<0.001), progressive hepatic inflammation (p = 0.029) and fibrosis severity (p = 0.010). There was a trend to an association between IMCL and decreased Akt phosphorylation (p = 0.059), despite no association with insulin resistance. In turn, hepatic steatosis (p = 0.015) and inflammation ...Continue Reading

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Citations

Nov 7, 2013·Pediatric Research·David E Brumbaugh, Jacob E Friedman
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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
biopsy
biopsies
enzymatic assay

Software Mentioned

GraphPad
PC160PLS
Quantity One
GraphPad InStat
Motic Images Advanced
SPSS

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