Liver cancer: effects, safety, and cost-effectiveness of controlled-release oxycodone for pain control after TACE

Radiology
Bo ZhouZuxing Kan

Abstract

To evaluate the analgesic effect, safety, and cost-effectiveness of controlled-release oxycodone (CRO) to control postoperative pain in patients with liver cancer who are undergoing transarterial chemoembolization. This randomized, double-blind, placebo-controlled, prospective clinical study received institutional review board approval. After written informed consent was obtained, 210 patients with liver cancer were randomized into three groups of 70 patients. Group 1 received 20 mg of CRO, group 2 received 10 mg of CRO, and group 3 received a placebo at 1 hour before transarterial chemoembolization (T(0)) and 12 (T(12)) and 24 (T(24)) hours after T(0). Pain intensity on a numeric rating scale, percentage of patients with each degree of pain, quality of life, adverse reactions, analgesic costs, and hospital stays were evaluated and compared among the three groups. Numeric rating scale scores for pain intensity in group 1 and group 2 were significantly lower than those in group 3 at T(0-12) (P < .001); T(12-24) (P < .001); and T(24-48) (P < .001). When group 1 with group 2 were compared, numeric rating scale scores were significantly lower in group 1 than in group 2 during the period of T(0-12) (P < .001) but were not significan...Continue Reading

References

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Citations

Feb 11, 2014·Japanese Journal of Radiology·Shiro MiyayamaYasuo Nakajima
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiao-Di GongBin Jiang
Nov 7, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Wen-Zhou ZhangBao-Xia He
Jul 19, 2016·Academic Radiology·Richard B Gunderman, Brian D Fogler
Aug 17, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Joseph BenzakounValérie Vilgrain
Jan 27, 2017·Oncology Letters·Geng ZhangHai-Lun Wang
Apr 12, 2018·Revista da Associação Médica Brasileira·Yi-Feng WuMing-Liang Chen
Jan 29, 2020·Current Medical Imaging Reviews·Muhammet Arslan, Serkan Degirmencioglu
Sep 3, 2020·World Journal of Gastroenterology : WJG·Li-Fang BianYan Zheng

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