PMID: 2499977Jan 1, 1989Paper

Liver cell shedding and phagocytic reaction in alcoholic liver disease. An ultrastructural study

Virchows Archiv. A, Pathological Anatomy and Histopathology
K A Bardadin, P J Scheuer

Abstract

Sinusoidal macrophages were studied by light and electron microscopy in 49 liver biopsies from alcohol-abusers with a variety of alcohol-related liver lesions or with near-normal livers. Changes were related to those in nearby hepatocytes. A reduction in the number of macrophages was noted in the more severely damaged livers. Hepatocytes formed blebs at their sinusoidal poles, and these protruded into the space of Disse and into the sinusoidal lumen. It is postulated that reduced phagocytic activity in the livers of patients with severe alcohol-related liver disease leads to increased shedding of hepatocellular material into the circulation. This may promote the development of autoimmune reactions directed against hepatocytes.

References

Nov 1, 1978·The Journal of Pathology·A M RobertsonA R Currie
Dec 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·M E De BroeF Roels
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M E LafonC Balabaud
Oct 1, 1985·The Journal of Pathology·L R Mills, P J Scheuer
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Sep 1, 1982·Journal of Clinical Pathology·G HoldstockR Wright
Jan 1, 1981·Scandinavian Journal of Gastroenterology·G LahnborgL Berghem

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Citations

Feb 1, 1991·Alcoholism, Clinical and Experimental Research·K G IshakM B Ray
Jun 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C VidalV Cuervas-Mons
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·W Lukita-AtmadjaK Wake
Jan 1, 1992·Critical Reviews in Clinical Laboratory Sciences·S W French
Nov 13, 1991·Biochimica Et Biophysica Acta·A R Beaudoin, G Grondin

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