PMID: 9648144Jul 2, 1998Paper

Liver changes in AIDS. Retrospective analysis of 227 autopsies of HIV-positive patients

Der Pathologe
A TrojanS Schröder

Abstract

In a retrospective study of a 12-year period (1981-1992) liver histology was analyzed in 227 autopsied patients infected with the human immunodeficiency virus. Normal histology could only be documented in 29 patients (13%). In the majority of cases (56%) uncharacteristic changes were seen such as steatosis (34%), hemosiderosis (10%) or non-specific reactive hepatitis (7%). The finding of hepatic peliosis obtained in 4 patients was not associated with inflammatory liver changes, especially infections from Rochalimaea. Within a wide range of opportunistic infections recorded in 50 patients (22%), hepatitis caused by Cytomegalovirus (8%), Toxoplasma gondii (5%), Leishmania donovani (1%), Cryptococcus neoformans and Pneumocystis carinii (each 0.5%) was diagnosed. Among 16 cases (7%) of mycobacterial liver infections typical mycobacteria were found in two patients and atypical mycobacteria in 14 patients, respectively. In 23 patients (10%) chronic viral hepatitis, caused by HBV (7%) or HCV infections (3%), respectively, was observed. Hepatitis was typed as mild only in each 5 patients with HBV or HCV infection, whereas the remaining cases showed a transition towards cirrhosis. Two patients with HBV-associated cirrhosis developed hep...Continue Reading

Citations

Aug 9, 2002·AIDS Research and Human Retroviruses·Thomas F KresinaLaura W Cheever
Jul 2, 2005·AIDS Patient Care and STDs·Maria RistigWilliam G Powderly
Feb 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Nancy Crum-CianfloneCharles Hames
Dec 4, 2004·AIDS·Massimo PuotiUNKNOWN HIV HCC Cooperative Italian-Spanish Group

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