Liver cirrhosis and cancer: comparison of mortality

Hepatology International
Wankyo ChungDong Joon Kim

Abstract

Liver cirrhosis is known to have low survival rate, and its assessment in relation with other fatal diseases will help us design appropriate health interventions. This study compares the mortality of liver cirrhosis with that of five major cancers (lung, colorectal, stomach, liver, and breast cancers). We used the National Health Insurance Service-National Sample Cohort (NHIS-NSC) which provides data for 1,025,340 representative samples of the 46,605,433 people in Korea from 2002 to 2010. During the 8 years, 800 out of 2609 liver cirrhosis patients died and 1316 out of 4852 patients with the five major cancers died. When we estimated the mortality between liver cirrhosis and five major cancers, the relative mortality for liver cirrhosis was greater [hazard ratio 1.47 (95% CI 1.28-1.67) after age, gender, area of residence, type of insurance, insurance premium level (proxy for income level), and comorbidities were adjusted for]. When a sensitivity analysis was performed by excluding patients with both liver cirrhosis and one of the five cancers, the relative mortality was still greater for liver cirrhosis [hazard ratio 1.27 (95% CI 1.10-1.47)]. Furthermore, when we limited liver cirrhosis patients to those with decompensated liv...Continue Reading

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Citations

Jan 4, 2019·Molecular Genetics & Genomic Medicine·Yingai ZhangHailong Zhou
Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Thevaraajan JayaramanSanjiv Mahadeva
Apr 22, 2018·Hepatology International·Martin C S Wong, Junjie Huang
Jan 16, 2021·International Journal of Environmental Research and Public Health·Ming-Shun HsiehVivian Chia-Rong Hsieh
Jul 28, 2020·The Journal of Surgical Research·Yuliya B OlimpiadiJulie E Lang
Feb 23, 2021·Asian Journal of Pharmaceutical Sciences·Lei XingHulin Jiang
Jun 11, 2021·World Journal of Surgical Oncology·Yu-Xi ChengZheng-Qiang Wei
Aug 18, 2021·The Korean Journal of Internal Medicine·Dongsub JeonJonggi Choi

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