Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity

World Journal of Gastrointestinal Pathophysiology
Elias TsiompanidisNikolaos Tentolouris

Abstract

To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy (CAN). A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval (QTc) and their dispersions (dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of CAN was based upon the battery of the tests proposed by Ewing and Clarke and the consensus statements of the American Diabetes Association. CAN was diagnosed when two out of the four classical Ewing tests were abnormal. QT, QTc and their dispersions were significantly longer (P< 0.01) in patients with cirrhosis than in controls. No significant differences in QT interval were found among the subgroups according to the etiology of cirrhosis. Multivariate regression analysis after controlling for age, gender and duration of cirrhosis demonstrated significant association between QT and presence of diabetes mellitus [standardized regression coefficient (beta) = 0.45,P= 0.02] and treatment with diuretics (beta = 0.55,P= 0.03), but not with the Child-Pugh score (P= 0.54). Prevalence of CAN was common (54.9%) among patients with cirrhosis and its severity was ...Continue Reading

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Citations

Mar 11, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Chaudry Nasir MajeedElsayed Z Soliman
Mar 11, 2020·Medicina·Joice Anaize Tonon do AmaralAna Cristina Aoun Tannuri
Jun 17, 2019·Current Gastroenterology Reports·Kelly E Diaz, Thomas D Schiano
Aug 7, 2019·Journal of Cardiovascular and Thoracic Research·Alireza MoarefYaser Bahramvand
Nov 12, 2020·Medicinal Research Reviews·Enrico Maria ZardiDomenico Maria Zardi
May 9, 2021·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Wei ZhaoLouis Saravolatz
Dec 16, 2020·Clinical and Molecular Hepatology·Ki Tae YoonSamuel S Lee

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

VariaCardio
SPSS

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