Abstract
To determine the risk of cancer in cohorts of patients with alcoholic cirrhosis, other alcoholic liver diseases, other and unspecified cirrhosis, primary biliary cirrhosis, viral hepatitis, acute pancreatitis and chronic pancreatitis compared with the risk in a control cohort. Analysis of statistical database of linked hospital and mortality data in an area in southern England. Compared with the control cohort, rate ratios were elevated for cancer overall and were particularly high for liver cancer in patients with alcoholic cirrhosis (rate ratio for cancer overall 2.4, 95% confidence interval 2.0-3.0 and 27.8, 17.7-41.7 for liver cancer); with other and unspecified cirrhosis (3.1, 2.7-3.6 and 35.1, 25.4-47.6); with other alcoholic liver diseases (2.3, 2.0-2.7 and 17.7, 11.5-26.0); with primary biliary cirrhosis (1.4, 0.9-2.0 and 19.6, 8.4-39.1) and with viral hepatitis (1.5, 1.2-1.9 and 18.6, 9.8-32.2). Pancreatic cancer risk was significantly and substantially elevated in all cohorts except that with primary biliary cirrhosis. Lung cancer risk was significantly high in all cohorts except those with primary biliary cirrhosis and viral hepatitis. Oral cavity cancers were elevated in alcoholic cirrhosis cohort (8.6; 3.1-18.9) an...Continue Reading
References
Feb 13, 1992·The New England Journal of Medicine·A L Warshaw, C Fernández-del Castillo
Dec 7, 1985·British Medical Journal·B M GoudieG Watkinson
Jun 1, 1984·The American Journal of Medicine·A M WolkeH S Sacks
Jul 1, 1995·Gastroenterology·P Bansal, A Sonnenberg
Jul 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L LööfB O Ryden
Apr 20, 1994·Journal of the National Cancer Institute·A EkbomJ F Fraumeni
Mar 1, 1993·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L LombardoM De La Pierre
May 20, 1993·The New England Journal of Medicine·A B LowenfelsL Domellöf
Aug 1, 1997·Gastroenterology·B M KarlsonO Nyrén
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H T SorensenJ Olsen
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P K NijhawanK D Lindor
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A FloreaniR Naccarato
Oct 13, 1999·Gut·D HowelO F James
Oct 13, 2000·QJM : Monthly Journal of the Association of Physicians·M GoldacreL Gill
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KuperO Nyrén
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·M V Apte, J S Wilson
Mar 17, 2005·British Journal of Cancer·M J GoldacreD Yeates
Apr 7, 2005·British Journal of Cancer·M J GoldacreD Yeates
Oct 4, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Michael J GoldacreValerie Seagroat
Nov 9, 2005·Fertility and Sterility·Michael J GoldacreDavid Yeates
Citations
Dec 1, 2010·Diabetologia·C J WottonM J Goldacre
Sep 2, 2009·International Journal of Epidemiology·Yuan-Chin Amy LeeKurt Straif
Sep 20, 2012·Surgery·Junji UedaUNKNOWN Research Committee of Intractable Diseases of the Pancreas
Oct 30, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Evangelos KalaitzakisEinar Björnsson
Jun 1, 2010·Best Practice & Research. Clinical Gastroenterology·Sara RaimondiRaffaele Pezzilli
Apr 17, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan LiangRenqian Zhong
Dec 14, 2011·Molecular Carcinogenesis·Sara H Olson
Mar 8, 2011·Cancer·Annelie M LandgrenLindsay M Morton
Nov 22, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Giuseppe CabibboAntonio Craxì
Jan 13, 2016·International Journal of Cancer. Journal International Du Cancer·Perttu SahlmanMartti Färkkilä
Jun 22, 2015·Surgical Oncology·C SabbaghJ M Regimbeau
May 11, 2016·The Journal of Laryngology and Otology·K-P ChangH-J Chang
Apr 29, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Peter JepsenHendrik Vilstrup
Dec 25, 2016·Gastrointestinal Endoscopy·Yuga KomakiAtsushi Sakuraba
Oct 16, 2015·BMJ Open Gastroenterology·Jonathan MontomoliHenrik Toft Sørensen
Dec 24, 2010·The American Journal of Gastroenterology·Kenneth BermanNaga Chalasani
Aug 2, 2017·The American Journal of Gastroenterology·Jakob KirkegårdDeirdre Cronin-Fenton
Dec 24, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C-C ChinJ-M Chiang
Aug 26, 2018·Transboundary and Emerging Diseases·Mohamed El-TholothKamel I Abou El-Azm
Mar 23, 2017·The Veterinary Quarterly·Kuldeep DhamaRaj Kumar Singh
Feb 13, 2014·Physiological Genomics·Brad RybinskiEdna Cukierman
Dec 15, 2015·Medicine·Li-Min SunChiao-Yi Lu
Oct 21, 2016·MedChemComm·Bibiana I FerreiraJames B Lorens
Feb 20, 2020·Current Opinion in Gastroenterology·Richard Parker
Jun 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexander W M HainingArmando Del Río Hernández
Jul 10, 2019·BMC Surgery·Zhenjiang ZhengXubao Liu
Aug 20, 2020·Tumori·Sevki KonurYusuf Kayar
May 1, 2020·Clinical and Translational Gastroenterology·Christie Y JeonBechien U Wu
Jan 24, 2020·The FEBS Journal·Maria Rafaeva, Janine T Erler
May 6, 2020·International Journal of Environmental Research and Public Health·Xiao-Min MuJia Feng
Feb 21, 2018·Inflammatory Bowel Diseases·Hanna M J L HazenbergGreetje J Tack Md PhD
Jul 22, 2019·Current Treatment Options in Gastroenterology·Michael W Gleeson
Oct 20, 2020·World Journal of Surgery·Dimitrios SchizasKonstantinos Toutouzas
Nov 25, 2020·Journal of Clinical Medicine·Miroslav VujasinovicJohannes-Matthias Löhr
Jan 11, 2021·Cancer Epidemiology·R D McDowellC R Cardwell
May 1, 2021·Journal of Clinical Medicine·Maria J Monroy-IglesiasAida Santaolalla
Jul 3, 2021·Frontiers in Immunology·Daria M Kartasheva-EbertzSylvie Lagaye