PMID: 8615368May 1, 1996Paper

Liver copper storage and transport during development: implications for cytotoxicity

The American Journal of Clinical Nutrition
S C Luza, H C Speisky

Abstract

Copper is an essential trace element for many biological processes. Its functions range from influencing specific gene expression to serving as a cofactor or prosthetic group for several enzymes. Intakes of copper at doses that exceed physiologic demands are normally met with efficient homeostatic mechanisms. Ceruloplasmin, albumin, and transcuprein, and to a lesser extent certain amino acids, are major copper-transporting constituents in circulating plasma. After its hepatic uptake, copper may be stored within hepatocytes, secreted into plasma, or excreted in bile. The biliary route represents the major excretory pathway of copper and largely accounts for its hepatic turnover. Copper retained by hepatocytes is mostly bound to specific metal-binding proteins, primarily metallothionein, or incorporated into several cuproenzymes. Copper incorporation into metallothionein and certain cuproproteins appears to require prior binding of copper to glutathione, thus defining a relation between copper metabolism and the intracellular availability of glutathione. Hepatic metallothionein concentrations can be modulated by dietary copper; changes in metallothionein and in copper status are significant throughout development. Binding of copp...Continue Reading

Citations

Dec 11, 2002·Journal of Gastroenterology and Hepatology·Anand N Pankit, Sheila A Bhave
Sep 12, 2015·Environmental Science and Pollution Research International·Mingyang JingRutao Liu
Apr 1, 2018·Journal of Animal Physiology and Animal Nutrition·T TomasiA S Da Silva
Jun 23, 2018·Metallomics : Integrated Biometal Science·Thao V NguyenTim Young
Sep 19, 2019·Biomedizinische Technik. Biomedical Engineering·Chao ZhouHaijun Zhang
Feb 16, 2005·Apoptosis : an International Journal on Programmed Cell Death·E A Ostrakhovitch, M G Cherian
Jan 18, 2006·Digestive Diseases and Sciences·Lorenzo LeggioGiovanni Gasbarrini
Nov 16, 2004·American Journal of Therapeutics·Robert W GorterEloy Pulido Cobian
Feb 27, 2008·The Journal of Pharmacology and Experimental Therapeutics·Ming SongCraig J McClain
Aug 14, 2008·World Journal of Gastroenterology : WJG·S SanthoshG M Chandy
Oct 31, 2008·Journal of Biochemical and Molecular Toxicology·Albena AlexandrovaMarian Kukan
May 21, 2010·Journal of Clinical Gastroenterology·Kassem BaradaJulnar Usta
Mar 3, 2011·The Journal of Clinical Investigation·Hans ZischkaGuido Kroemer
Aug 8, 2013·Expert Opinion on Drug Discovery·Milorad CakicIvana M Savic
Jun 14, 2019·Veterinary Medicine International·Jaimie M StricklandJohn P Buchweitz
Feb 8, 2006·Applied and Environmental Microbiology·Marcel SchmittHella Lichtenberg-Fraté
Oct 4, 2012·Animal : an International Journal of Animal Bioscience·M García-VaqueroM Miranda
Oct 31, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ricardo Gutiérrez-GarcíaMauricio González
Jul 25, 2009·Journal of Applied Toxicology : JAT·M E LetelierR Marín-Catalán
Mar 1, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kushal NahaBarkur Ananthakrishna Shastry
Dec 30, 1998·The Journal of Nutrition·A J FascettiQ R Rogers
Feb 10, 2016·Alcoholism, Clinical and Experimental Research·Ming SongCraig J McClain
May 25, 2012·New Zealand Veterinary Journal·A A YigitE Yildirim
Mar 13, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Constantinos MichosAggelos Evangelou
Feb 1, 2011·Metallomics : Integrated Biometal Science·Bibudhendra Sarkar, Eve A Roberts
Dec 17, 2019·Journal of Animal Physiology and Animal Nutrition·Yang GaoLianyu Yang
Apr 20, 2016·Archives of Environmental Contamination and Toxicology·Estefanía BonnailT Ángel DelValls
Mar 1, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I JiménezH Speisky
Feb 24, 2001·Journal of Hepatology·S M Riordan, R Williams
Dec 4, 2003·Biochimica Et Biophysica Acta·Gianna FerrettiGiovanna Curatola
Sep 7, 1999·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·J H Menkes
Nov 4, 2004·American Journal of Medical Genetics. Part a·Eleni PanagiotakakiEmmanuel Kanavakis
Feb 9, 2005·Chemico-biological Interactions·María Eugenia LetelierHernán Speisky

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