Liver damage associated with occupational exposure to organic solvents in house painters

European Journal of Clinical Investigation
M DøssingL Ranek

Abstract

Among 156 patients admitted to hospital because of suspected solvent intoxication or dementia following long-term occupational exposure to organic solvents, twenty-three had elevated aminotransferases in serum. In thirteen of these no particular cause of this elevation could be found and the chronic exposure to aliphatic and aromatic organic solvents is therefore likely to have played a pathogenetic role and a liver biopsy was performed. Liver histology revealed significant steatosis in eleven patients and in six of these focal necroses were also observed. Moreover, six of the biopsies showed enlarged portal tracts with fibrosis. Necrosis was only observed in liver specimens from patients who recently had been exposed to solvents. A causal relation between occupational exposure to aliphatic and aromatic organic solvents such as white spirit, xylene, toluene and styrene, and toxic liver injury is suggested by this descriptive study but needs confirmation.

References

Jul 1, 1978·Drugs·H J Zimmerman
May 1, 1979·The Medical Clinics of North America·C H Tamburro
Jan 1, 1977·Scandinavian Journal of Gastroenterology·P Petersen
Jun 1, 1977·Scandinavian Journal of Work, Environment & Health·M HaneB Ydreborg
Mar 1, 1976·Scandinavian Journal of Work, Environment & Health·O AxelsonC Hogstedt
Sep 1, 1966·Toxicology and Applied Pharmacology·D E RectorJ Siegel
Apr 3, 1971·British Medical Journal·E T O'BrienJ A Hobby
Jan 1, 1980·Acta Pharmacologica Et Toxicologica·J Järvisalo, H Vainio

❮ Previous
Next ❯

Citations

Jan 23, 1999·American Journal of Industrial Medicine·G LundqvistO Axelson
Jan 1, 1985·International Archives of Occupational and Environmental Health·L M Pedersen
Jan 1, 1993·International Archives of Occupational and Environmental Health·Y UchidaM Ikeda
May 1, 1993·Archives of Environmental Health·T SkovE Lynge
Sep 1, 1985·British Journal of Industrial Medicine·I Lundberg, M Håkansson
Nov 1, 1990·British Journal of Industrial Medicine·P B BethwaiteJ Fraser
Oct 1, 1991·British Journal of Industrial Medicine·J D ChenY Y Chen
Oct 1, 1995·Occupational and Environmental Medicine·C A BrodkinD Gretch
Oct 1, 1996·Occupational and Environmental Medicine·V ArndtT M Fliedner
Sep 4, 1999·Occupational and Environmental Medicine·R ChenA Seaton
Feb 1, 1988·British Journal of Industrial Medicine·R J McCunney
Jun 1, 2008·Clinical Journal of Gastroenterology·Hideaki KatoMasataka Nagao
Feb 1, 1987·Pharmacology & Toxicology·L M PedersenC H Cohr
Nov 29, 2002·International Journal of Hygiene and Environmental Health·Nachman Brautbar, John Williams
Jan 1, 1986·Journal of Hepatology·M Døssing
Aug 24, 1999·Seizure : the Journal of the British Epilepsy Association·K R Kaufman
Aug 24, 2011·Toxicology and Industrial Health·Mehmet Kanter
Dec 25, 2012·Toxicologic Pathology·Banrida WahlangMatt C Cave
Sep 12, 2008·Human & Experimental Toxicology·S OlgarU Aydogan
Jan 1, 1984·Acta Neurologica Scandinavica. Supplementum·P Arlien-Søborg
Mar 27, 2002·International Journal of Health Services : Planning, Administration, Evaluation·Mauri Johansson, Timo Partanen
Nov 15, 1985·Klinische Wochenschrift·W K Lelbach
Oct 3, 1999·American Journal of Industrial Medicine·F TomeiM V Rosati
Nov 21, 1998·Cancer Detection and Prevention·R Chen, A Seaton
Jan 1, 1985·International Archives of Occupational and Environmental Health·M Døssing, P Skinhøj
Mar 4, 1991·The Medical Journal of Australia·A T KnightR C Newland

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