PMID: 69876Aug 6, 1977Paper

Liver damage from long-term methyltestosterone

Lancet
D WestabyI M Murray-Lyon

Abstract

Of 60 patients (42 female transsexuals and 18 impotent males) receiving long-term therapy with methyltestosterone 50 mg three times a day, 19 had abnormal liver-function tests and 33 out of 52 had abnormal liver scans, particularly those who had been treated for more than a year. Liver biopsy specimens showed accumulation of hepatocytes in the liver cords and within the walls of centrilobular veins, and early peliosis hepatis. One patient had a hepatic adenoma. Of the androgens, only 17alpha-alkylated steroids seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumours.

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Related Concepts

Adenoma, Trabecular
Cholestasis
Subfertility, Male
Liver
Liver Function Tests
Malignant Neoplasm of Liver
Methitest
Petechiae
Transsexualism

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