PMID: 69876Aug 6, 1977Paper

Liver damage from long-term methyltestosterone

D WestabyI M Murray-Lyon


Of 60 patients (42 female transsexuals and 18 impotent males) receiving long-term therapy with methyltestosterone 50 mg three times a day, 19 had abnormal liver-function tests and 33 out of 52 had abnormal liver scans, particularly those who had been treated for more than a year. Liver biopsy specimens showed accumulation of hepatocytes in the liver cords and within the walls of centrilobular veins, and early peliosis hepatis. One patient had a hepatic adenoma. Of the androgens, only 17alpha-alkylated steroids seem to be implicated in the development of cholestatic jaundice, peliosis hepatis, and liver tumours.


Jan 1, 1987·Archives of Gynecology·E Kaiser, H S Gruner
Jul 1, 1984·European Journal of Drug Metabolism and Pharmacokinetics·J F TempletonJ W Steele
Oct 7, 2010·Archives of Toxicology·Sylvi WolfOliver Zierau
Oct 22, 2005·Current Urology Reports·Stephen Lazarou, Abraham Morgentaler
Sep 4, 2013·Current Urology Reports·William P Conners, Abraham Morgentaler
Jan 16, 1995·The American Journal of Medicine·R Sands, J Studd
Jun 4, 1988·Lancet·P T ClaytonJ Sjövall
Aug 1, 1978·Gut·C DegottJ P Benhamou
Jul 1, 1979·Gut·S Sherlock
Apr 26, 2008·Endocrine Reviews·Stephanie T PageWilliam J Bremner
Aug 27, 2009·Therapeutics and Clinical Risk Management·Nazem BassilJohn E Morley
Feb 1, 1983·Allergy·L BergamaschiniA Agostoni
Jul 25, 1998·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·S P Dourakis, G Tolis
Oct 22, 2003·Clinics in Geriatric Medicine·Fran E Kaiser
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·A L ShefferK F Austen
Apr 1, 1991·The Journal of Allergy and Clinical Immunology·M CicardiA Agostoni
Jan 8, 2014·Histopathology·Elizabeth M BruntIan R Wanless
Jun 1, 1991·Clinical Pediatrics·J D HannaJ C Chan
Nov 1, 1984·The American Journal of Sports Medicine·H A Haupt, G D Rovere
Jan 1, 1984·The American Journal of Sports Medicine·D R Lamb
Jul 12, 2002·Journal of the American Geriatrics Society·Maria Clara M PaderoTheodore C Friedman
Aug 14, 2018·The British Journal of Dermatology·C C MotoskoA Hazen
Feb 1, 1979·Cancer·F W StromeyerK G Ishak
Dec 1, 1978·The British Journal of Surgery·G B CoombesI Burn
Feb 26, 2005·Clinical and Experimental Immunology·M M GompelsD Watters
Jun 1, 1982·Gut·M J FarthingT J McElwain
Apr 1, 1980·International Journal of Andrology·H KloerE Nieschlag
Oct 1, 1990·Postgraduate Medical Journal·P J WinwoodR Wright
Jan 1, 1985·Postgraduate Medical Journal·C K ffrench-ConstantG R Thompson
Jul 7, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marcus Maurer, Markus Magerl
Jun 11, 2009·The Journal of Clinical Endocrinology and Metabolism·Wylie C HembreeEndocrine Society
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·K K Miller
Sep 8, 1998·Archives of Andrology·E Velázquez, G Bellabarba Arata
May 3, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Mikio NamikiJapanese Urological Association/Japanese Society for Study of Aging Male
Jul 1, 1989·Medical Toxicology and Adverse Drug Experience·R C HicksonM T Falduto
Oct 16, 2010·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Marcus Maurer, Markus Magerl
Mar 14, 2012·European Journal of Gastroenterology & Hepatology·Ugochukwu C Nzeako, Hilary J Longhurst
Jan 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Fiona YuenStephanie T Page
Oct 21, 2004·American Journal of Hematology·Isela Velazquez, Blanche P Alter
Apr 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Willem G E J SchoonenJack T W E Vogels
Sep 16, 1999·Menopause : the Journal of the North American Menopause Society·N GitlinH M Yang
Feb 1, 1981·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J W SteeleR C Audette
May 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Ronald S SwerdloffTheodore M Danoff
Aug 26, 1998·The Journal of Clinical Endocrinology and Metabolism·K MillerS Grinspoon
Feb 17, 2005·The Journal of Clinical Endocrinology and Metabolism·John K Amory, William J Bremner
May 24, 1986·British Medical Journal·D FormanR Doll

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