PMID: 12755473May 21, 2003Paper

Liver death and regeneration in paracetamol toxicity

Human & Experimental Toxicology
A H McGregorD J Harrison

Abstract

Paracetamol overdose (POD) is a major clinical problem as the commonest cause of fulminant hepatic failure (FHF) in the UK and the USA. While the main loss of liver mass occurs following hepatocyte necrosis, hepatocyte apoptosis has also been reported to occur during paracetamol toxicity in murine liver. Hepatocyte apoptosis has not previously been identified in human liver and the significance of apoptosis in paracetamol toxicity is not known. In this study of paracetamol toxicity in human liver after POD, hepatocyte apoptosis was identified at time of liver transplantation or death and was associated with striking regenerative activity. The biological significance of apoptosis is unclear but the rates of apoptosis found (0.6%) could account for a significant loss of hepatic parenchyma. The stimulus for apoptosis is not known but it is unlikely to be induced directly by paracetamol since it is absent from serum at this time. The possibility that apoptosis may be induced by Kupffer cell activation with cytokine production is raised. Patients who develop FHF after POD have a poor prognosis, with few therapeutic options apart from liver transplantation; an understanding of the dynamics of liver regeneration and ongoing cell loss ...Continue Reading

References

Jul 21, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·M LesnaO F James
Aug 1, 1989·Gastroenterology·J G O'GradyR Williams
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R R PelemanT E Starzl
Apr 15, 1987·Biochemical Pharmacology·J B BartoloneE A Khairallah
Aug 1, 1995·The Journal of Pathology·S C AffordJ M Neuberger
Jul 1, 1995·Toxicology and Applied Pharmacology·M E BlazkaM I Luster
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·D L Laskin, K J Pendino
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D L LaskinD J Jollow
Jan 1, 1995·Life Sciences·R Rognstad
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Oct 1, 1993·Pharmacology & Therapeutics·S H Thomas
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B W DonaldsonL M Blendis
Jan 1, 1996·Toxicologic Pathology·T L GoldsworthyR R Maronpot
Aug 1, 1996·The Journal of Pathology·R D GoldinS N Wickramasinghe
Dec 7, 1996·BMJ : British Medical Journal·E Fagan, G Wannan
Feb 7, 1997·Cell·A G PaulovichL H Hartwell
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B Grasl-KrauppR Schulte-Hermann
Apr 1, 1997·Gastroenterology·A T Axon
Jan 1, 1997·Journal of Hepatology·J G O'Grady
Aug 1, 1997·Journal of Hepatology·P R Galle
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W BernalR Williams
Jun 2, 1998·Seminars in Liver Disease·T PatelG J Gores
Jun 2, 1998·Seminars in Liver Disease·G FanC J Steer
Jun 2, 1998·Seminars in Liver Disease·P R Galle, P H Krammer
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L MichaelJ A Hinson
Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PatelG J Gores

❮ Previous
Next ❯

Citations

Mar 22, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xin FuK Barry Delclos
Oct 17, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bishnupada RoyAnanta Swargiary
Apr 18, 2014·Archives of Physiology and Biochemistry·Maysa Ahmed Mobasher, Ángela M Valverde
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Ludger LeifeldUlrich Spengler
May 12, 2010·Basic & Clinical Pharmacology & Toxicology·Sa'ed H ZyoudSamah W Al-Jabi
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Darren G N CraigKenneth J Simpson
Jul 16, 2011·Microscopy Research and Technique·Mateus FerreiraMaria Izabel Camargo Mathias
Jul 16, 2010·Human & Experimental Toxicology·Sa'ed H ZyoudSamah W Al-Jabi
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pallavi B LimayeHarihara M Mehendale
May 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yong ChenJianping Gong
Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liangcai LinShanggao Liao
Aug 12, 2004·The Journal of Biological Chemistry·Stefan KrautwaldUlrich Kunzendorf

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
James W Dear
Toxicological Sciences : an Official Journal of the Society of Toxicology
Janet DowdyM R Miller
© 2022 Meta ULC. All rights reserved