Liver-derived ketone bodies are necessary for food anticipation

Nature Communications
Rohit ChavanUrs Albrecht

Abstract

The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific deletion of Per2 in mice abolishes FA, an effect that is rescued by viral overexpression of Per2 in the liver. RNA sequencing indicates that Per2 regulates β-hydroxybutyrate (βOHB) production to induce FA leading to the conclusion that liver Per2 is important for this process. Unexpectedly, we show that FA originates in the liver and not in the brain. However, manifestation of FA involves processing of the liver-derived βOHB signal in the brain, indicating that the food-entrainable oscillator is not located in a single tissue but is of systemic nature.

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Datasets Mentioned

BETA
SRP058086

Methods Mentioned

BETA
PCR
electrophoresis
RNA-Seq
Assay

Software Mentioned

LEICA
Clocklab
LumiCycle
Actimetrics
Pathway studio
iPRECIO IMS
Integrative Genomics Viewer
Quantity One
R
VitalView

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