Liver directed therapy for renal cell carcinoma.

Journal of Cancer
Russell C LanganItzhak Avital

Abstract

Metastatic renal cell carcinoma (RCC) to the liver portrays a poor prognosis and liver directed therapy remains controversial. We aimed to determine potential selection criteria for patients who might benefit from this strategy. We evaluated 247 consecutive patients with RCC metastatic to the liver from a prospectively maintained database. Eighteen patients received liver directed therapy (18/247, 7%). Ten patients underwent liver resection (10/247, 4%) and eight patients underwent radiofrequency ablation (RFA, 8/247, 3%). All were rendered free of disease in the liver. Five had synchronous liver disease and underwent synchronous resections with their primary. Mortality was 0%. Fourteen had single (surgery 7, RFA 7) and four (surgery 3, RFA 1) had multiple liver lesions, respectively. Median size of lesions was 5cm (0.5 - 10cm) and 2.5cm (1 - 6cm) in the surgery and RFA groups, respectively. Median DFI was 10 months, and no difference was observed in those with a longer vs. shorter than median DFI (p = 0.95); liver specific progression free survival for the surgery and RFA groups were 4 and 6 months, respectively (p= 0.93). 1, 3 and 5-year actuarial survivals for the whole group were 89%, 40%, 27%. Median survival for the surge...Continue Reading

Citations

Sep 18, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·N G GrimesH Z Malik
Aug 26, 2014·Langenbeck's Archives of Surgery·Timothy L FitzgeraldEmmanuel E Zervos
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Jan 6, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Astrid BauschkeUtz Settmacher

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