Liver dysfunction in patients with severe anorexia nervosa

The International Journal of Eating Disorders
Elissa RosenPhilip S Mehler

Abstract

Evaluation of liver dysfunction in patients with severe anorexia nervosa (AN) has typically been limited to small case series. We report an investigation into the admission characteristics and clinical outcomes associated with liver dysfunction in a large cohort of adults hospitalized for medical stabilization of severe AN. We retrospectively evaluated electronic medical records to quantify the cumulative incidence of elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT). We compared mean (±SD), frequencies (%), and median (IQR) values of clinical covariates of interest by incidence of liver enzyme elevation. The study included 181 adults, admitted for medical stabilization of AN, from October 1, 2008 to December 31, 2013. AST and ALT were mildly elevated in 27.6% of patients and severely elevated (more than three times the upper limit of normal) in 35.4% of patients. On admission, patients with severely elevated liver enzymes had a lower body mass index (BMI) (11.9 ± 1.8 kg/m(2) vs.13.3 ± 1.7 kg/m(2)), lower percentage ideal body weight (56.5% ± 7.7% vs. 63.5% ± 8.3%), and lower prealbumin (64% vs. 37%) compared with the rest of the cohort (p < 0.001). While hospitalized, patients with severely elevated ...Continue Reading

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Citations

Nov 26, 2015·The International Journal of Eating Disorders·Jennifer L Gaudiani, Philip S Mehler
Apr 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Catherine M GordonMichelle P Warren
Jan 13, 2019·The International Journal of Eating Disorders·Aiko KogaKeisuke Kawai
Jun 26, 2020·Journal of Eating Disorders·Dennis GibsonPhilip S Mehler
Nov 1, 2016·Journal of General Internal Medicine·Adam C NadelsonVilas R Patwardhan
Apr 24, 2018·Eating and Weight Disorders : EWD·Dennis GibsonPhilip S Mehler
Sep 22, 2017·Digestive Diseases and Sciences·Elissa RosenPhilip S Mehler
Nov 6, 2020·Eating and Weight Disorders : EWD·Renata RisiMikiko Watanabe
Oct 8, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Marie GuinhutMouna Hanachi
Jun 8, 2021·Inflammatory Bowel Diseases·Graziella Rangel PanizMonia E Werlang
Jul 3, 2021·Journal of Clinical Medicine·Leah PuckettPhilip Mehler

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Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

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