PMID: 11914100Mar 27, 2002Paper

Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs

Clinical Science
J Guy FinchG J Maddern

Abstract

Electrolysis is a method of tissue ablation that creates chemical species and a pH gradient in response to direct current. Initial studies of electrolysis in animal models and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study tested whether pH could be used as a real-time monitor in order to predict more accurately the extent of necrosis. A total of 70 electrolytic lesions were created in 14 pigs, with pH monitoring of the lesion edge. The normal range of pH values was 6.5-8.7. A pH of less than 6 (at the anode) or more than 9 (at the cathode) reflected total cellular necrosis. When a pH value was recorded between 6.0 and 6.5 at the anode or between 8.7 and 9.0 at the cathode, the presence of necrosis was variable. In conclusion, during electrolytic ablation, pH measurement can monitor the extent of the induced necrosis.

Citations

Mar 15, 2011·Annals of Biomedical Engineering·Antoni Ivorra
Oct 3, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G GarceaD P Berry
May 12, 2011·PloS One·Pablo TurjanskiGuillermo Marshall
Nov 28, 2013·PloS One·Felipe MagliettiGuillermo Marshall
Sep 14, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ralf CzymekAndreas Schmidt
Apr 7, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M S MetcalfeG J Maddern
Jun 26, 2010·ANZ Journal of Surgery·Christopher D MannAshley R Dennison
Jan 13, 2015·Bioelectrochemistry·Fabio L CurySimone Chevalier
Jun 4, 2015·PloS One·Arie Meir, Boris Rubinsky

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