Liver enzymes and ultrastructure in rabbit haemorrhagic disease (RHD)

Veterinary Research Communications
P G FerreiraArtur P Aguas

Abstract

Rabbit haemorrhagic disease (RHD) is caused by a calicivirus infection that kills most adult rabbits 24-72 h after viral inoculation. Two liver enzymes (AST, aspartate aminotransferase, and ALT, alanine aminotransferase) were monitored in blood samples of calicivirus-infected rabbits during the short course of RHD. Values of AST were used to differentiate three stages of hepatocellular degeneration in RHD: mild (up to 20-fold increase in AST), moderate (150-200-fold elevation of AST) and severe (more than 1000-fold elevation in AST). Liver samples of rabbits from these three biochemical stages of hepatocellular degeneration of RHD were studied by transmission electron microscopy to define the fine structure of the hepatocytes. In the mild hepatocellular degeneration there was proliferation (microvesiculation) of the smooth endoplasmic reticulum and swelling of mitochondria into spheroid bodies with loss of cristae. In moderate hepatocellular degeneration, vacuolization of cytoplasm and mitochondrial damage continued to be present, and there was also formation of autophagic vesicles. In the severe hepatocellular degeneration of RHD, the altered mitochondria also showed loss of density of their matrix; rupture of cytoplasmic vacu...Continue Reading

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Citations

Aug 11, 2010·Veterinary Research Communications·Raquel M MarquesPaula G Ferreira
Feb 14, 2012·Veterinary Research·Joana AbrantesPedro J Esteves
Oct 24, 2008·Experimental Animals·Sheng-Yi ChenHong-Kean Ooi
Sep 10, 2010·Research in Veterinary Science·Luzia TeixeiraPaula G Ferreira
Apr 21, 2006·Research in Veterinary Science·P G FerreiraA P Aguas
Mar 13, 2019·Veterinary Clinical Pathology·Cristina BonvehíSara Ekei Ferrera
Oct 9, 2008·The Journal of Veterinary Medical Science·Sheng-Yi ChenJui-Hung Shien
Oct 24, 2019·Veterinary World·Anna Babken SemerjyanZaven Alexandr Karalyan
Jul 21, 2020·Autophagy·Sophie TesseraudIban Seiliez

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