Abstract
Benzbromarone is a uricosuric agent that reduces proximal tubular reabsorption of uric acid. Because of hepatotoxicity, it has been withdrawn from the market in Europe. Recently, some benefit-risk assessments of benzbromarone suggest that benzbromarone has greater benefits than risks, and the application of benzbromarone in the treatment of gout and hyperuricemia is still under debate. A 39-year-old man was admitted to the hospital for icterus and nausea, and he was treated with benzbromarone (100 mg/d) for 4 mo because of hyperuricemia. He had a 10-year history of beer drinking (alcohol: about 28 g/d). Laboratory data showed severe liver injury and serious coagulation dysfunction; tests for autoimmune antibodies, viral hepatitis, and human immunodeficiency virus were negative. Despite administration of liver function-protecting drugs and efficient supportive treatment, the patient deteriorated quickly after hospitalization and developed grade II encephalopathy within a few days. The patient accepted continuous plasma exchange six times; however, his condition did not improve. Based on suggestions from multidisciplinary consultation, the patient underwent liver transplantation 26 d after admission. Liver specimen pathology resu...Continue Reading
References
Mar 1, 1972·European Journal of Clinical Pharmacology·J BroekhuysenM Van Hee
Mar 1, 1994·Journal of Hepatology·M M van der KlauwP Spoelstra
Jun 14, 2000·Journal of Hepatology·H WagayamaY Tameda
Jun 27, 2002·Journal of Gastroenterology and Hepatology·Makoto AraiHiromitsu Saisho
Mar 31, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Priska KaufmannStephan Krähenbühl
May 19, 2006·Annals of the Rheumatic Diseases·W ZhangUNKNOWN EULAR Standing Committee for International Clinical Studies Including Therapeutics
Nov 21, 2007·Chemical Research in Toxicology·Matthew G McDonald, Allan E Rettie
Jul 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ming-Han H LeeRichard O Day
Aug 31, 2012·Biopharmaceutics & Drug Disposition·Kaoru KobayashiKan Chiba
Dec 1, 2012·European Journal of Gastroenterology & Hepatology·Bernhard HaringAndreas Geier
Aug 12, 2014·Toxicology·Andrea FelserStephan Krähenbühl
Jul 8, 2015·Toxicology and Applied Pharmacology·Maho ShirakawaKousei Ito
Jul 8, 2015·Nature Reviews. Rheumatology·Chang-Fu KuoMichael Doherty
Oct 30, 2016·Lancet·Nicola DalbethLisa K Stamp
Jul 13, 2016·Case Reports in Gastroenterology·Yuki HagaOsamu Yokosuka
Jan 31, 2017·Drug Metabolism and Pharmacokinetics·Naoki ChoKan Chiba
Jun 10, 2017·Journal of Biochemical and Molecular Toxicology·Mina YoshidaKaoru Kobayashi
Jul 28, 2017·Journal of Advanced Research·Gaafar RagabThomas Bardin
Oct 13, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hui WangJiang Zheng